Severe Statin-induced Rhabdomyolysis following Cholestatic Hepatitis induced by Amoxicillin-clavulanate

We report the case of an 86-year-old man with a past history of coronary disease admitted to our internal medicine department for severe asthenia and weakness due to rhabdomyolysis. Three days earlier, he had been discharged from a gastroenterology unit with a diagnosis of amoxicillin–clavulanate-in...

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Bibliographic Details
Main Authors: Rachele Rapetti, Elena Merlotti, Mattia Bellan, Gian Piero Schianca, Mario Pirisi
Format: Article
Language:English
Published: SMC MEDIA SRL 2014-05-01
Series:European Journal of Case Reports in Internal Medicine
Subjects:
Online Access:http://ejcrim.com/index.php/EJCRIM/article/view/65
Description
Summary:We report the case of an 86-year-old man with a past history of coronary disease admitted to our internal medicine department for severe asthenia and weakness due to rhabdomyolysis. Three days earlier, he had been discharged from a gastroenterology unit with a diagnosis of amoxicillin–clavulanate-induced acute cholestatic hepatitis. A review of his drugs revealed that he had taken atorvastatin 10 mg daily in the previous six years, without clinical or laboratory signs of myopathy. Atorvastatin was therefore stopped, with gradual improvement of the rhabdomyolysis. All concomitant drug therapy needs to be reassessed in elderly patients, especially when they become acutely ill.
ISSN:2284-2594