Developmental Immaturity of Siglec Receptor Expression on Neonatal Alveolar Macrophages Predisposes to Severe Group B Streptococcal Infection
Summary: Streptococcus agalactiae (Group B Streptococcus, GBS) is the most common neonatal pathogen. However, the cellular and molecular mechanisms for neonatal susceptibility to GBS pneumonia and sepsis are incompletely understood. Here we optimized a mouse model of GBS pneumonia to test the role o...
Main Authors: | Sean J. Lund, Kathryn A. Patras, Jacqueline M. Kimmey, Asami Yamamura, Lindsay D. Butcher, Pamela G.B. Del Rosario, Gilberto E. Hernandez, Alyssa M. McCoy, Omar Lakhdari, Victor Nizet, Lawrence S. Prince |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-06-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220303928 |
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