Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population
Aims: Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness and debilitating in old stages, in developed and developing countries that engage the central part of the retina or macula. The aim of this study was to evaluate the relationship of the rs4151667 posit...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Gonabad University of Medical Sciences (GMU)
2017-09-01
|
Series: | Ufuq-i Dānish |
Subjects: | |
Online Access: | http://hms.gmu.ac.ir/article-1-2657-en.pdf |
id |
doaj-08ab9d22806e4d3dba607696aa98c44d |
---|---|
record_format |
Article |
spelling |
doaj-08ab9d22806e4d3dba607696aa98c44d2020-11-24T23:06:41ZengGonabad University of Medical Sciences (GMU)Ufuq-i Dānish1735-18552252-08052017-09-01233174180Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran PopulationN. Roshani Pour0 M. Jabbarpour Bonyadi1 M.H. Jabbarpour Bonyadi2Center of excellence for bio diversity Department, Natural Sciences Faculty, University of Tabriz, Tabriz, Iran Post Address: Natural Sciences Faculty, University of Tabriz, 29 Bahman Street, Tabriz, Iran , jabbarpour@tabrizu.ac.irOphthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Aims: Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness and debilitating in old stages, in developed and developing countries that engage the central part of the retina or macula. The aim of this study was to evaluate the relationship of the rs4151667 position of the complement factor B gene polymorphism with AMD (dry type with geographic atrophy phenotype) in the North East of Iran population. Materials & Methods: In this descriptive cross-sectional study in 2015-2016, 44 AMD patients (dry type with geographic atrophy phenotype) were randomly selected from Gonabad City, Iran, health centers as the patient group. 50 healthy individuals from the same society that have no relative relations with each other or the patients, but were adapted by age and sex to the patient group, were selected as the control group. The polymorphism of rs4151667 (c.26T>A) position of the complement factor B gene was determined for all samples by Restriction Fragment Length Polymorphism (RFLP). Data was analyzed the Chi-square test in 2x2.Contingency software. Findings: The frequency of TT genotype in AMD patients (95.5%) was significantly (p=0.048) more than the control group (88.0%), but the frequency of AT genotype in AMD patients (4.5%) was significantly (p=0.025) less than the control group (12.0%). Conclusion: The polymorphism of rs4151667 (c.26T>A) position of complement factor B is effective on the development of AMD in North East of Iran population.http://hms.gmu.ac.ir/article-1-2657-en.pdfAge-related macular degenerationComplement Factor BPolymorphismGenetic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
N. Roshani Pour M. Jabbarpour Bonyadi M.H. Jabbarpour Bonyadi |
spellingShingle |
N. Roshani Pour M. Jabbarpour Bonyadi M.H. Jabbarpour Bonyadi Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population Ufuq-i Dānish Age-related macular degeneration Complement Factor B Polymorphism Genetic |
author_facet |
N. Roshani Pour M. Jabbarpour Bonyadi M.H. Jabbarpour Bonyadi |
author_sort |
N. Roshani Pour |
title |
Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population |
title_short |
Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population |
title_full |
Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population |
title_fullStr |
Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population |
title_full_unstemmed |
Effect of Complement Factor B Gene Polymorphisms on Age-Related Macular Degeneration in North-East of Iran Population |
title_sort |
effect of complement factor b gene polymorphisms on age-related macular degeneration in north-east of iran population |
publisher |
Gonabad University of Medical Sciences (GMU) |
series |
Ufuq-i Dānish |
issn |
1735-1855 2252-0805 |
publishDate |
2017-09-01 |
description |
Aims: Age-related macular degeneration (AMD) is the most prevalent cause of irreversible blindness and debilitating in old stages, in developed and developing countries that engage the central part of the retina or macula. The aim of this study was to evaluate the relationship of the rs4151667 position of the complement factor B gene polymorphism with AMD (dry type with geographic atrophy phenotype) in the North East of Iran population.
Materials & Methods: In this descriptive cross-sectional study in 2015-2016, 44 AMD patients (dry type with geographic atrophy phenotype) were randomly selected from Gonabad City, Iran, health centers as the patient group. 50 healthy individuals from the same society that have no relative relations with each other or the patients, but were adapted by age and sex to the patient group, were selected as the control group. The polymorphism of rs4151667 (c.26T>A) position of the complement factor B gene was determined for all samples by Restriction Fragment Length Polymorphism (RFLP). Data was analyzed the Chi-square test in 2x2.Contingency software.
Findings: The frequency of TT genotype in AMD patients (95.5%) was significantly (p=0.048) more than the control group (88.0%), but the frequency of AT genotype in AMD patients (4.5%) was significantly (p=0.025) less than the control group (12.0%).
Conclusion: The polymorphism of rs4151667 (c.26T>A) position of complement factor B is effective on the development of AMD in North East of Iran population. |
topic |
Age-related macular degeneration Complement Factor B Polymorphism Genetic |
url |
http://hms.gmu.ac.ir/article-1-2657-en.pdf |
work_keys_str_mv |
AT nroshanipour effectofcomplementfactorbgenepolymorphismsonagerelatedmaculardegenerationinnortheastofiranpopulation AT mjabbarpourbonyadi effectofcomplementfactorbgenepolymorphismsonagerelatedmaculardegenerationinnortheastofiranpopulation AT mhjabbarpourbonyadi effectofcomplementfactorbgenepolymorphismsonagerelatedmaculardegenerationinnortheastofiranpopulation |
_version_ |
1725621760108265472 |