Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study
Background and Purpose: We investigated the risk factors for death in patients with medullary infarction (MI) during a long-term follow-up.Methods: We retrospectively examined 179 consecutive patients (130 men and 49 women) who had clinical and MRI findings consistent with MI between February 2012 a...
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doaj-08b551082e54434daaf71993aca986672021-03-04T05:51:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-03-011210.3389/fneur.2021.615230615230Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up StudyDao Pei Zhang0Xiang Zhe Liu1Suo Yin2Qian Kun Ma3Meng Yu4Huai Liang Zhang5Xin Zhi Wang6Jie Wen Zhang7Department of Neurology, The First Affiliated Hospital of Henan University of CM, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Henan University of CM, Zhengzhou, ChinaDepartment of Image, People's Hospital of Henan University of CM, Zhengzhou, ChinaDepartment of Image, People's Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurology, People's Hospital of Henan University of CM, Zhengzhou, ChinaDepartment of Neurology, The First Affiliated Hospital of Henan University of CM, Zhengzhou, ChinaDepartment of Image, The First Affiliated Hospital of Henan University of CM, Zhengzhou, ChinaDepartment of Neurolgoy, People's Hospital of Zhengzhou University, Zhengzhou, ChinaBackground and Purpose: We investigated the risk factors for death in patients with medullary infarction (MI) during a long-term follow-up.Methods: We retrospectively examined 179 consecutive patients (130 men and 49 women) who had clinical and MRI findings consistent with MI between February 2012 and January 2017 at three university hospitals. Long-term outcomes were assessed by telephonic interview. The clinical and radiological features and risk factors for poor outcomes (modified Rankin scale score ≥ 3, all-cause death) were analyzed.Results: Mean age of patients was 58.3 ± 12.8 years (range, 25–87); mean follow-up period after stroke onset was 42.7 ± 13.2 months (range, 24–78). Basilar artery (BA) stenosis >50% was more closely related to medial medullary infarction (MMI) than other types. There was greater frequency of ipsilateral vertebral artery hypoplasia (VAH) or V4AH and V4 occlusion in lateral MI than in other types. On rostro-caudal classification, middle (M)+dorsal (D) was most frequent, followed by the ventral (V)+M+D types. 21.2% patients showed poor long-term prognosis. Age ≥ 65 years, recurrent stroke, dysphagia, >50% BA stenosis, and ventral MI were risk factors for poor long-term prognosis. All-cause mortality rate was 10.6%; age ≥ 65 years, recurrent stroke, and dysphagia were risk factors for death in the long-term. Ventral MI and MMI+cerebellar infarction, as well as stroke mechanism of artery-to-artery embolism, were potential risk factors for death in the long-term. Pneumonia and recurrent stroke were major causes of death.Conclusions: Long-term poor outcomes of MI and all-cause mortality were not infrequent. Older age, recurrent stroke, and dysphagia were common risk factors for poor prognosis and death.https://www.frontiersin.org/articles/10.3389/fneur.2021.615230/fullmedullary infarctionprognosisdeathrisk factorsstroke |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dao Pei Zhang Xiang Zhe Liu Suo Yin Qian Kun Ma Meng Yu Huai Liang Zhang Xin Zhi Wang Jie Wen Zhang |
spellingShingle |
Dao Pei Zhang Xiang Zhe Liu Suo Yin Qian Kun Ma Meng Yu Huai Liang Zhang Xin Zhi Wang Jie Wen Zhang Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study Frontiers in Neurology medullary infarction prognosis death risk factors stroke |
author_facet |
Dao Pei Zhang Xiang Zhe Liu Suo Yin Qian Kun Ma Meng Yu Huai Liang Zhang Xin Zhi Wang Jie Wen Zhang |
author_sort |
Dao Pei Zhang |
title |
Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study |
title_short |
Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study |
title_full |
Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study |
title_fullStr |
Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study |
title_full_unstemmed |
Risk Factors for Long-Term Death After Medullary Infarction: A Multicenter Follow-Up Study |
title_sort |
risk factors for long-term death after medullary infarction: a multicenter follow-up study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2021-03-01 |
description |
Background and Purpose: We investigated the risk factors for death in patients with medullary infarction (MI) during a long-term follow-up.Methods: We retrospectively examined 179 consecutive patients (130 men and 49 women) who had clinical and MRI findings consistent with MI between February 2012 and January 2017 at three university hospitals. Long-term outcomes were assessed by telephonic interview. The clinical and radiological features and risk factors for poor outcomes (modified Rankin scale score ≥ 3, all-cause death) were analyzed.Results: Mean age of patients was 58.3 ± 12.8 years (range, 25–87); mean follow-up period after stroke onset was 42.7 ± 13.2 months (range, 24–78). Basilar artery (BA) stenosis >50% was more closely related to medial medullary infarction (MMI) than other types. There was greater frequency of ipsilateral vertebral artery hypoplasia (VAH) or V4AH and V4 occlusion in lateral MI than in other types. On rostro-caudal classification, middle (M)+dorsal (D) was most frequent, followed by the ventral (V)+M+D types. 21.2% patients showed poor long-term prognosis. Age ≥ 65 years, recurrent stroke, dysphagia, >50% BA stenosis, and ventral MI were risk factors for poor long-term prognosis. All-cause mortality rate was 10.6%; age ≥ 65 years, recurrent stroke, and dysphagia were risk factors for death in the long-term. Ventral MI and MMI+cerebellar infarction, as well as stroke mechanism of artery-to-artery embolism, were potential risk factors for death in the long-term. Pneumonia and recurrent stroke were major causes of death.Conclusions: Long-term poor outcomes of MI and all-cause mortality were not infrequent. Older age, recurrent stroke, and dysphagia were common risk factors for poor prognosis and death. |
topic |
medullary infarction prognosis death risk factors stroke |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2021.615230/full |
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