Asthma-COPD overlap is not a homogeneous disorder: further supporting data
Abstract Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients...
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doaj-08b86f6e05b64637a5823e29173e69092020-11-24T21:40:03ZengBMCRespiratory Research1465-993X2017-11-011811410.1186/s12931-017-0667-xAsthma-COPD overlap is not a homogeneous disorder: further supporting dataLuis Pérez-de-Llano0Borja G. Cosio1on behalf of the CHACOS study groupDepartment of Respiratory Medicine, Hospital Lucus AugustiDepartment of Respiratory Medicine, Hospital Universitario Son Espases-IdISBaAbstract Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-α, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions.http://link.springer.com/article/10.1186/s12931-017-0667-xEosinophilsPeriostinCOPDAsthmaAsthma-COPD overlapACO |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luis Pérez-de-Llano Borja G. Cosio on behalf of the CHACOS study group |
spellingShingle |
Luis Pérez-de-Llano Borja G. Cosio on behalf of the CHACOS study group Asthma-COPD overlap is not a homogeneous disorder: further supporting data Respiratory Research Eosinophils Periostin COPD Asthma Asthma-COPD overlap ACO |
author_facet |
Luis Pérez-de-Llano Borja G. Cosio on behalf of the CHACOS study group |
author_sort |
Luis Pérez-de-Llano |
title |
Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
title_short |
Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
title_full |
Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
title_fullStr |
Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
title_full_unstemmed |
Asthma-COPD overlap is not a homogeneous disorder: further supporting data |
title_sort |
asthma-copd overlap is not a homogeneous disorder: further supporting data |
publisher |
BMC |
series |
Respiratory Research |
issn |
1465-993X |
publishDate |
2017-11-01 |
description |
Abstract Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-α, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions. |
topic |
Eosinophils Periostin COPD Asthma Asthma-COPD overlap ACO |
url |
http://link.springer.com/article/10.1186/s12931-017-0667-x |
work_keys_str_mv |
AT luisperezdellano asthmacopdoverlapisnotahomogeneousdisorderfurthersupportingdata AT borjagcosio asthmacopdoverlapisnotahomogeneousdisorderfurthersupportingdata AT onbehalfofthechacosstudygroup asthmacopdoverlapisnotahomogeneousdisorderfurthersupportingdata |
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