New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study
Abstract Background New-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Furthermore, little is known regarding the association between NOAF and resour...
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doaj-08b90e573cfb4700875fd54b27eac10c2021-01-17T12:20:02ZengBMCCritical Care1364-85352020-01-0124111010.1186/s13054-020-2730-0New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort studyShannon M. Fernando0Rebecca Mathew1Benjamin Hibbert2Bram Rochwerg3Laveena Munshi4Allan J. Walkey5Morten Hylander Møller6Trevor Simard7Pietro Di Santo8F. Daniel Ramirez9Peter Tanuseputro10Kwadwo Kyeremanteng11Division of Critical Care, Department of Medicine, University of OttawaDivision of Critical Care, Department of Medicine, University of OttawaDivision of Cardiology, University of Ottawa Heart InstituteDepartment of Medicine, Division of Critical Care, McMaster UniversityInterdepartmental Division of Critical Care Medicine, University of TorontoDepartment of Medicine, The Pulmonary Center, Boston University School of MedicineDepartment of Intensive Care, Copenhagen University Hospital RighospitaletDivision of Cardiology, University of Ottawa Heart InstituteDivision of Cardiology, University of Ottawa Heart InstituteDivision of Cardiology, University of Ottawa Heart InstituteClinical Epidemiology Program, Ottawa Hospital Research InstituteDivision of Critical Care, Department of Medicine, University of OttawaAbstract Background New-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Furthermore, little is known regarding the association between NOAF and resource use or hospital costs. Methods Retrospective analysis (2011–2016) of a prospectively collected registry from two Canadian hospitals of consecutive ICU patients aged ≥ 18 years. We excluded patients with a known history of AF prior to hospital admission. Any occurrence of atrial fibrillation (AF) was prospectively recorded by bedside nurses. The primary outcome was hospital mortality, and we used multivariable logistic regression to adjust for confounders. We used a generalized linear model to evaluate contributors to total cost. Results We included 15,014 patients, and 1541 (10.3%) had NOAF during their ICU admission. While NOAF was not associated with increased odds of hospital death among the entire cohort (adjusted odds ratio [aOR] 1.02 [95% confidence interval [CI] 0.97–1.08]), an interaction was noted between NOAF and sepsis, and the presence of both was associated with higher odds of hospital mortality (aOR 1.28 [95% CI 1.09–1.36]) than either alone. Patients with NOAF had higher total costs (cost ratio [CR] 1.09 [95% CI 1.02–1.20]). Among patients with NOAF, treatment with a rhythm-control strategy was associated with higher costs (CR 1.24 [95% CI 1.07–1.40]). Conclusions While NOAF was not associated with death or requiring discharge to long-term care among critically ill patients, it was associated with increased length of stay in ICU and increased total costs.https://doi.org/10.1186/s13054-020-2730-0Atrial fibrillationCritical careIntensive care unitResource utilizationCosts |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shannon M. Fernando Rebecca Mathew Benjamin Hibbert Bram Rochwerg Laveena Munshi Allan J. Walkey Morten Hylander Møller Trevor Simard Pietro Di Santo F. Daniel Ramirez Peter Tanuseputro Kwadwo Kyeremanteng |
spellingShingle |
Shannon M. Fernando Rebecca Mathew Benjamin Hibbert Bram Rochwerg Laveena Munshi Allan J. Walkey Morten Hylander Møller Trevor Simard Pietro Di Santo F. Daniel Ramirez Peter Tanuseputro Kwadwo Kyeremanteng New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study Critical Care Atrial fibrillation Critical care Intensive care unit Resource utilization Costs |
author_facet |
Shannon M. Fernando Rebecca Mathew Benjamin Hibbert Bram Rochwerg Laveena Munshi Allan J. Walkey Morten Hylander Møller Trevor Simard Pietro Di Santo F. Daniel Ramirez Peter Tanuseputro Kwadwo Kyeremanteng |
author_sort |
Shannon M. Fernando |
title |
New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study |
title_short |
New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study |
title_full |
New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study |
title_fullStr |
New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study |
title_full_unstemmed |
New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study |
title_sort |
new-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study |
publisher |
BMC |
series |
Critical Care |
issn |
1364-8535 |
publishDate |
2020-01-01 |
description |
Abstract Background New-onset atrial fibrillation (NOAF) is commonly encountered in critically ill adults. Evidence evaluating the association between NOAF and patient-important outcomes in this population is conflicting. Furthermore, little is known regarding the association between NOAF and resource use or hospital costs. Methods Retrospective analysis (2011–2016) of a prospectively collected registry from two Canadian hospitals of consecutive ICU patients aged ≥ 18 years. We excluded patients with a known history of AF prior to hospital admission. Any occurrence of atrial fibrillation (AF) was prospectively recorded by bedside nurses. The primary outcome was hospital mortality, and we used multivariable logistic regression to adjust for confounders. We used a generalized linear model to evaluate contributors to total cost. Results We included 15,014 patients, and 1541 (10.3%) had NOAF during their ICU admission. While NOAF was not associated with increased odds of hospital death among the entire cohort (adjusted odds ratio [aOR] 1.02 [95% confidence interval [CI] 0.97–1.08]), an interaction was noted between NOAF and sepsis, and the presence of both was associated with higher odds of hospital mortality (aOR 1.28 [95% CI 1.09–1.36]) than either alone. Patients with NOAF had higher total costs (cost ratio [CR] 1.09 [95% CI 1.02–1.20]). Among patients with NOAF, treatment with a rhythm-control strategy was associated with higher costs (CR 1.24 [95% CI 1.07–1.40]). Conclusions While NOAF was not associated with death or requiring discharge to long-term care among critically ill patients, it was associated with increased length of stay in ICU and increased total costs. |
topic |
Atrial fibrillation Critical care Intensive care unit Resource utilization Costs |
url |
https://doi.org/10.1186/s13054-020-2730-0 |
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