Location of Balanced Chromosome-Translocation Breakpoints by Long-Read Sequencing on the Oxford Nanopore Platform

Location of Balanced Chromosome-Translocation Breakpoints by Long-Read Sequencing on the Oxford Nanopore Platform

Genomic structural variants, including translocations, inversions, insertions, deletions, and duplications, are challenging to be reliably detected by traditional genomic technologies. In particular, balanced translocations and inversions can neither be identified by microarrays since they do not al...

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Bibliographic Details
Main Authors: Liang Hu, Fan Liang, Dehua Cheng, Zhiyuan Zhang, Guoliang Yu, Jianjun Zha, Yang Wang, Qi Xia, Daoli Yuan, Yueqiu Tan, Depeng Wang, Yu Liang, Ge Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Genetics
Subjects:
Oxford Nanopore Technologies
structural variants
balanced translocation
long-read sequencing
preimplantation genetic testing
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01313/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.01313/full

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