Intermittent Hypoxia-Induced Renal Antioxidants and Oxidative Damage in Male Mice: Hormetic dose Response
Obstructive sleep apnea causes cardiovascular disease via chronic intermittent hypoxia (IH), which may be related to oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important cellular defense mechanism against oxidative stress by regulating its down-stream multiple antioxi...
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Series: | Dose-Response |
Online Access: | https://doi.org/10.2203/dose-response.12-027.Cai |
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doaj-08bf58e92ca74d09b3b36b5e2b6d08a32020-11-25T02:34:07ZengSAGE PublishingDose-Response1559-32582013-07-011110.2203/dose-response.12-027.CaiIntermittent Hypoxia-Induced Renal Antioxidants and Oxidative Damage in Male Mice: Hormetic dose ResponseWeixia SunXia YinYuehui WangYi TanLu CaiBo WangJun CaiYaowen FuObstructive sleep apnea causes cardiovascular disease via chronic intermittent hypoxia (IH), which may be related to oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important cellular defense mechanism against oxidative stress by regulating its down-stream multiple antioxidants. The present study was to define whether IH can induce renal pathogenic damage and if so, whether Nrf2 and its down-stream antioxidants are involved in IH-induced pathogenic changes. Mice were culled for exposure to intermittent air as control or IH that consisted of 20.9% O 2 /8% O 2 F I O 2 alternation cycles (30 episodes per h) with 20 seconds at the nadir F I O 2 for 12 h a day during daylight. Short-term IH exposure (3 −7 days) induced significant increases in renal inflammatory response and antioxidant levels along with a reduction of the spontaneous content of malondialdehyde while long-term IH exposure (8 weeks) induced a significant decrease of antioxidant levels and significant increases of renal inflammation, oxidative damage, cell death, and fibrosis. This study suggests that IH induces a hormetic response, i.e.: short-term IH exposure is able to induce a protective response to protect the kidney from oxidative damage while long-term IH exposure is able to induce a damage effect on the kidney.https://doi.org/10.2203/dose-response.12-027.Cai |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Weixia Sun Xia Yin Yuehui Wang Yi Tan Lu Cai Bo Wang Jun Cai Yaowen Fu |
spellingShingle |
Weixia Sun Xia Yin Yuehui Wang Yi Tan Lu Cai Bo Wang Jun Cai Yaowen Fu Intermittent Hypoxia-Induced Renal Antioxidants and Oxidative Damage in Male Mice: Hormetic dose Response Dose-Response |
author_facet |
Weixia Sun Xia Yin Yuehui Wang Yi Tan Lu Cai Bo Wang Jun Cai Yaowen Fu |
author_sort |
Weixia Sun |
title |
Intermittent Hypoxia-Induced Renal Antioxidants and Oxidative Damage in Male Mice: Hormetic dose Response |
title_short |
Intermittent Hypoxia-Induced Renal Antioxidants and Oxidative Damage in Male Mice: Hormetic dose Response |
title_full |
Intermittent Hypoxia-Induced Renal Antioxidants and Oxidative Damage in Male Mice: Hormetic dose Response |
title_fullStr |
Intermittent Hypoxia-Induced Renal Antioxidants and Oxidative Damage in Male Mice: Hormetic dose Response |
title_full_unstemmed |
Intermittent Hypoxia-Induced Renal Antioxidants and Oxidative Damage in Male Mice: Hormetic dose Response |
title_sort |
intermittent hypoxia-induced renal antioxidants and oxidative damage in male mice: hormetic dose response |
publisher |
SAGE Publishing |
series |
Dose-Response |
issn |
1559-3258 |
publishDate |
2013-07-01 |
description |
Obstructive sleep apnea causes cardiovascular disease via chronic intermittent hypoxia (IH), which may be related to oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important cellular defense mechanism against oxidative stress by regulating its down-stream multiple antioxidants. The present study was to define whether IH can induce renal pathogenic damage and if so, whether Nrf2 and its down-stream antioxidants are involved in IH-induced pathogenic changes. Mice were culled for exposure to intermittent air as control or IH that consisted of 20.9% O 2 /8% O 2 F I O 2 alternation cycles (30 episodes per h) with 20 seconds at the nadir F I O 2 for 12 h a day during daylight. Short-term IH exposure (3 −7 days) induced significant increases in renal inflammatory response and antioxidant levels along with a reduction of the spontaneous content of malondialdehyde while long-term IH exposure (8 weeks) induced a significant decrease of antioxidant levels and significant increases of renal inflammation, oxidative damage, cell death, and fibrosis. This study suggests that IH induces a hormetic response, i.e.: short-term IH exposure is able to induce a protective response to protect the kidney from oxidative damage while long-term IH exposure is able to induce a damage effect on the kidney. |
url |
https://doi.org/10.2203/dose-response.12-027.Cai |
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