Spectrum of somatic mutations detected by targeted next-generation sequencing and their prognostic significance in adult patients with acute lymphoblastic leukemia

Spectrum of somatic mutations detected by targeted next-generation sequencing and their prognostic significance in adult patients with acute lymphoblastic leukemia

Abstract Target-specific next-generation sequencing technology was used to analyze 112 genes in adult patients with acute lymphoblastic leukemia (ALL). This sequencing mainly focused on the specific mutational hotspots. Among the 121 patients, 93 patients were B-ALL (76.9%), and 28 patients (23.1%)...

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Bibliographic Details
Main Authors: Juan Feng, Yan Li, Yujiao Jia, Qiuyun Fang, Xiaoyuan Gong, Xiaobao Dong, Kun Ru, Qinghua Li, Xingli Zhao, Kaiqi Liu, Min Wang, Zheng Tian, Yannan Jia, Ying Wang, Dong Lin, Hui Wei, Kejing Tang, Yingchang Mi, Jianxiang Wang
Format: Article
Language:English
Published: BMC 2017-02-01
Series:Journal of Hematology & Oncology
Subjects:
Next-generation sequencing
Somatic mutations
Prognostic significance
Acute lymphoblastic leukemia
Online Access:http://link.springer.com/article/10.1186/s13045-017-0431-1

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