Environmental toxin acrolein alters levels of endogenous lipids, including TRP agonists: A potential mechanism for headache driven by TRPA1 activation

Environmental toxin acrolein alters levels of endogenous lipids, including TRP agonists: A potential mechanism for headache driven by TRPA1 activation

Exposure to airborne toxins can trigger headaches, but the mechanisms are not well understood. Some environmental toxins, such as acrolein, activate transient receptor potential ankyrin 1 (TRPA1), a receptor involved in pain sensation that is highly expressed in the trigeminovascular system. It has...

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Bibliographic Details
Main Authors: Emma Leishman, Phillip E. Kunkler, Meera Manchanda, Kishan Sangani, Jordyn M. Stuart, Gerry S. Oxford, Joyce H. Hurley, Heather B. Bradshaw
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Neurobiology of Pain
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X17300028

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