Surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancer
Abstract Colorectal cancer is a major public health problem worldwide, and locally advanced rectal cancer (LARC) is known for its poor prognosis. A multimodal treatment approach is the only method to achieve satisfactory local recurrence and survival rates in LARC. Determining which therapeutic moda...
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Online Access: | https://doi.org/10.1002/kjm2.12161 |
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doaj-08d145dde3fd4cbebeb6d7c3e7b654ed2020-11-25T02:09:55ZengWileyKaohsiung Journal of Medical Sciences1607-551X2410-86502020-03-0136315215910.1002/kjm2.12161Surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancerMing‐Yii Huang0Ching‐Wen Huang1Jaw‐Yuan Wang2Department of Radiation Oncology Kaohsiung Medical University Hospital Kaohsiung TaiwanDivision of Colorectal Surgery, Department of Surgery Kaohsiung Medical University Hospital Kaohsiung TaiwanGraduate Institute of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung TaiwanAbstract Colorectal cancer is a major public health problem worldwide, and locally advanced rectal cancer (LARC) is known for its poor prognosis. A multimodal treatment approach is the only method to achieve satisfactory local recurrence and survival rates in LARC. Determining which therapeutic modality for LARC has the most satisfactory influence on quality of life and disease outcome is still controversial. LARC treatment is subject to continuous advancement due to the development of new and better diagnostic tools, radiotherapy techniques, and chemotherapeutic agents. Herein, we review various therapeutic modalities for LARC from several aspects. In addition to radiotherapy techniques such as neoadjuvant chemoradiotherapy (NCRT), we discuss the progress of chemotherapy, appropriate time interval between NCRT and surgery, relationship between tumor location and NCRT efficacy/safety, wait‐and‐watch policy, and predictors of treatment response following NCRT. Because of the controversies and unanswered questions regarding NCRT treatments for LARC, additional investigations are required to determine which therapeutic approach is the most feasible for LARC patients.https://doi.org/10.1002/kjm2.12161local recurrencelocally advanced rectal cancerneoadjuvant chemoradiotherapysurgery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming‐Yii Huang Ching‐Wen Huang Jaw‐Yuan Wang |
spellingShingle |
Ming‐Yii Huang Ching‐Wen Huang Jaw‐Yuan Wang Surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancer Kaohsiung Journal of Medical Sciences local recurrence locally advanced rectal cancer neoadjuvant chemoradiotherapy surgery |
author_facet |
Ming‐Yii Huang Ching‐Wen Huang Jaw‐Yuan Wang |
author_sort |
Ming‐Yii Huang |
title |
Surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancer |
title_short |
Surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancer |
title_full |
Surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancer |
title_fullStr |
Surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancer |
title_full_unstemmed |
Surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancer |
title_sort |
surgical treatment following neoadjuvant chemoradiotherapy in locally advanced rectal cancer |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X 2410-8650 |
publishDate |
2020-03-01 |
description |
Abstract Colorectal cancer is a major public health problem worldwide, and locally advanced rectal cancer (LARC) is known for its poor prognosis. A multimodal treatment approach is the only method to achieve satisfactory local recurrence and survival rates in LARC. Determining which therapeutic modality for LARC has the most satisfactory influence on quality of life and disease outcome is still controversial. LARC treatment is subject to continuous advancement due to the development of new and better diagnostic tools, radiotherapy techniques, and chemotherapeutic agents. Herein, we review various therapeutic modalities for LARC from several aspects. In addition to radiotherapy techniques such as neoadjuvant chemoradiotherapy (NCRT), we discuss the progress of chemotherapy, appropriate time interval between NCRT and surgery, relationship between tumor location and NCRT efficacy/safety, wait‐and‐watch policy, and predictors of treatment response following NCRT. Because of the controversies and unanswered questions regarding NCRT treatments for LARC, additional investigations are required to determine which therapeutic approach is the most feasible for LARC patients. |
topic |
local recurrence locally advanced rectal cancer neoadjuvant chemoradiotherapy surgery |
url |
https://doi.org/10.1002/kjm2.12161 |
work_keys_str_mv |
AT mingyiihuang surgicaltreatmentfollowingneoadjuvantchemoradiotherapyinlocallyadvancedrectalcancer AT chingwenhuang surgicaltreatmentfollowingneoadjuvantchemoradiotherapyinlocallyadvancedrectalcancer AT jawyuanwang surgicaltreatmentfollowingneoadjuvantchemoradiotherapyinlocallyadvancedrectalcancer |
_version_ |
1724921732425318400 |