Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of...

Full description

Bibliographic Details
Main Authors:	Zuqiang Liu, Roshni Ravindranathan, Pawel Kalinski, Z. Sheng Guo, David L. Bartlett
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14754

id	doaj-08d52995317b46989e958cc19d18bdfc
record_format	Article
spelling	doaj-08d52995317b46989e958cc19d18bdfc2021-05-11T07:29:00ZengNature Publishing GroupNature Communications2041-17232017-03-018111210.1038/ncomms14754Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacyZuqiang Liu0Roshni Ravindranathan1Pawel Kalinski2Z. Sheng Guo3David L. Bartlett4The University of Pittsburgh Cancer Institute, University of Pittsburgh School of MedicineThe University of Pittsburgh Cancer Institute, University of Pittsburgh School of MedicineThe University of Pittsburgh Cancer Institute, University of Pittsburgh School of MedicineThe University of Pittsburgh Cancer Institute, University of Pittsburgh School of MedicineThe University of Pittsburgh Cancer Institute, University of Pittsburgh School of MedicineAnti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of activated T cells, and reducing exhausted T cells.https://doi.org/10.1038/ncomms14754
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zuqiang Liu Roshni Ravindranathan Pawel Kalinski Z. Sheng Guo David L. Bartlett
spellingShingle	Zuqiang Liu Roshni Ravindranathan Pawel Kalinski Z. Sheng Guo David L. Bartlett Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy Nature Communications
author_facet	Zuqiang Liu Roshni Ravindranathan Pawel Kalinski Z. Sheng Guo David L. Bartlett
author_sort	Zuqiang Liu
title	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_short	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_full	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_fullStr	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_full_unstemmed	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_sort	rational combination of oncolytic vaccinia virus and pd-l1 blockade works synergistically to enhance therapeutic efficacy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-03-01
description	Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of activated T cells, and reducing exhausted T cells.
url	https://doi.org/10.1038/ncomms14754
work_keys_str_mv	AT zuqiangliu rationalcombinationofoncolyticvacciniavirusandpdl1blockadeworkssynergisticallytoenhancetherapeuticefficacy AT roshniravindranathan rationalcombinationofoncolyticvacciniavirusandpdl1blockadeworkssynergisticallytoenhancetherapeuticefficacy AT pawelkalinski rationalcombinationofoncolyticvacciniavirusandpdl1blockadeworkssynergisticallytoenhancetherapeuticefficacy AT zshengguo rationalcombinationofoncolyticvacciniavirusandpdl1blockadeworkssynergisticallytoenhancetherapeuticefficacy AT davidlbartlett rationalcombinationofoncolyticvacciniavirusandpdl1blockadeworkssynergisticallytoenhancetherapeuticefficacy
_version_	1721452091127365632

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

Similar Items