Transgenic Overexpression of the Proprotein Convertase Furin Enhances Skin Tumor Growth

Transgenic Overexpression of the Proprotein Convertase Furin Enhances Skin Tumor Growth

Furin, one of the members of the family of proprotein convertases (PCs), ubiquitously expressed as a type I membrane-bound proteinase, activates several proteins that contribute to tumor progression. In vitro studies using cancer cell lines and clinical specimens demonstrated that furin processes i...

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Bibliographic Details
Main Authors: Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Emmanuelle Nicolas, Andres J.P. Klein-Szanto
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800650

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