Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes
Methanol extract of Marrubium. sivasense Aytaç, Akgül & Ekici was analyzed with LC-MS/MS technique. Forsythoside B, verbascoside and leucoseptoside were identified as main compounds. Antioxidant properties of the extract was determined by DPPH free radical scavenging activity (IC50 0.34 mg/mL),...
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Turkish Chemical Society
2019-10-01
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| Series: | Journal of the Turkish Chemical Society, Section A: Chemistry |
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| Online Access: | https://dergipark.org.tr/en/pub/jotcsa/issue/46088/516888 |
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doaj-08d61e8b9a2d45b7bb9327e84d4111622020-11-25T00:30:28ZengTurkish Chemical SocietyJournal of the Turkish Chemical Society, Section A: Chemistry2149-01202149-01202019-10-0163281292https://doi.org/10.18596/jotcsa.516888Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymesFatih GöğerGülmira Özek Mehmet TekinSüleyman YurTemel Özek Methanol extract of Marrubium. sivasense Aytaç, Akgül & Ekici was analyzed with LC-MS/MS technique. Forsythoside B, verbascoside and leucoseptoside were identified as main compounds. Antioxidant properties of the extract was determined by DPPH free radical scavenging activity (IC50 0.34 mg/mL), trolox equivalent antioxidant capacity (TEAC) (2.3 mM±0.04), xanthine-xanthine oxidase(XO) inhibitory effect (16.54 %). and. B-carotene bleaching (Inh. 43±1.26 %) assays. The extract demonstrated hypoglycemic activity (Inh. 49.67±1.09 %.) via inhibition of porcine pancreatic α-amylase, the antiinflammatory effect of the extract tested via inhibition of 5-LOX was found as Inh 18.71±0.74 %, however no antityrosinase activity was found. https://dergipark.org.tr/en/pub/jotcsa/issue/46088/516888Marrubium sivasenseextractLC-MS/MSantioxidantα-Amylasexanthine oxidase |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Fatih Göğer Gülmira Özek Mehmet Tekin Süleyman Yur Temel Özek |
| spellingShingle |
Fatih Göğer Gülmira Özek Mehmet Tekin Süleyman Yur Temel Özek Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes Journal of the Turkish Chemical Society, Section A: Chemistry Marrubium sivasense extract LC-MS/MS antioxidant α-Amylase xanthine oxidase |
| author_facet |
Fatih Göğer Gülmira Özek Mehmet Tekin Süleyman Yur Temel Özek |
| author_sort |
Fatih Göğer |
| title |
Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes |
| title_short |
Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes |
| title_full |
Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes |
| title_fullStr |
Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes |
| title_full_unstemmed |
Phytochemical profiling and evaluation of Marrubium sivasense Aytaç, Akgül & Ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes |
| title_sort |
phytochemical profiling and evaluation of marrubium sivasense aytaç, akgül & ekici effects on oxidative damage, α-amylase, lipoxygenase, xanthine oxidase and tyrosinase enzymes |
| publisher |
Turkish Chemical Society |
| series |
Journal of the Turkish Chemical Society, Section A: Chemistry |
| issn |
2149-0120 2149-0120 |
| publishDate |
2019-10-01 |
| description |
Methanol extract of Marrubium. sivasense Aytaç, Akgül & Ekici was analyzed with LC-MS/MS technique. Forsythoside B, verbascoside and leucoseptoside were identified as main compounds. Antioxidant properties of the extract was determined by DPPH free radical scavenging activity (IC50 0.34 mg/mL), trolox equivalent antioxidant capacity (TEAC) (2.3 mM±0.04), xanthine-xanthine oxidase(XO) inhibitory effect (16.54 %). and. B-carotene bleaching (Inh. 43±1.26 %) assays. The extract demonstrated hypoglycemic activity (Inh. 49.67±1.09 %.) via inhibition of porcine pancreatic α-amylase, the antiinflammatory effect of the extract tested via inhibition of 5-LOX was found as Inh 18.71±0.74 %, however no antityrosinase activity was found. |
| topic |
Marrubium sivasense extract LC-MS/MS antioxidant α-Amylase xanthine oxidase |
| url |
https://dergipark.org.tr/en/pub/jotcsa/issue/46088/516888 |
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