Case Report: Refractory Hypotension of GABA B Receptor Autoimmune Encephalitis

• Main Authors: Kong Hanxin, Wang Xiaomin, Ying Hao, Zheng Shuihong
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-12-01
• Series: Frontiers in Neurology
• Subjects: GABA B receptor autoimmune encephalitis; refractory hypotension; autonomic nerve function; autoimmune disease; case report
• Online Access: https://www.frontiersin.org/articles/10.3389/fneur.2020.571382/full

Introduction: With the development of antibody detection technology, Gamma-Aminobutyric Acid (GABA) B receptor encephalitis is a known autoimmune disease. This paper describes a patient with refractory hypotension who suffered GABA B receptor autoimmune encephalitis.Case Report: We describe a 63-year-old man with GABA B receptor autoimmune encephalitis who had hypotension on day 17 of the disease onset. Despite two rounds of immunoglobulin administration, high-dose intravenous steroid injections and immunosuppressive therapy on day 35 of hospitalization, psychiatric symptoms and seizures were significantly improved; however, the patient's blood pressure remained low.Conclusion: This case study and literature review investigated the impairment of autonomic nerve function and its subsequent management in patients with GABA B receptor autoimmune encephalitis.