Evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty
This study isolated and quantified intestinal bacteria of children with cleft palate before and after palatoplasty. A prospective study was conducted from May 2007 to September 2008 on 18 children with cleft palate, aged one to four years, of both genders, attending a tertiary cleft center in Brazil...
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Sociedade Brasileira de Microbiologia
2013-09-01
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doaj-08e3bb289f3f453781c08c76fbd6c1542020-11-24T22:54:38ZengSociedade Brasileira de MicrobiologiaBrazilian Journal of Microbiology1678-44052013-09-0144383583810.1590/S1517-83822013000300026S1517-83822013000300026Evaluation of fecal microorganisms of children with cleft palate before and after palatoplastyNarciso Almeida Vieira0Hilton Coimbra Borgo1Gisele da Silva Dalben2Maria Irene Bachega3Paulo Câmara Marques Pereira4Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade Estadual PaulistaThis study isolated and quantified intestinal bacteria of children with cleft palate before and after palatoplasty. A prospective study was conducted from May 2007 to September 2008 on 18 children with cleft palate, aged one to four years, of both genders, attending a tertiary cleft center in Brazil for palatoplasty, to analyze the effect of surgical palate repair on the concentration of anaerobes Bacteroides sp, Bifidobacterium sp and microaerophiles Lactobacillus sp in feces of infants with cleft palate before and 24 hours after treatment with cefazolin for palatoplasty. There was significant reduction of Lactobacillus sp (p < 0.002), Bacteroides sp (p < 0.001) and Bifidobacterium sp (p = 0.021) after palatoplasty, revealing that surgery and utilization of cefazolin significantly influenced the fecal microbiota comparing collections before and after surgery. However, due to study limitations, it was not possible to conclude that other isolated factors, such as surgical stress, anesthetics and other medications used in palatoplasty might have a significant influence on the microbiota. Considering the important participation of the intestinal microbiota on both local and systemic metabolic and immunological activities of the host, professionals should be attentive to the possible influence of these changes in patients submitted to cleft repair.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000300026&lng=en&tlng=encleft palatecleft palate/surgeryenvironmental microbiologyfecessurgery/plastic |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Narciso Almeida Vieira Hilton Coimbra Borgo Gisele da Silva Dalben Maria Irene Bachega Paulo Câmara Marques Pereira |
spellingShingle |
Narciso Almeida Vieira Hilton Coimbra Borgo Gisele da Silva Dalben Maria Irene Bachega Paulo Câmara Marques Pereira Evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty Brazilian Journal of Microbiology cleft palate cleft palate/surgery environmental microbiology feces surgery/plastic |
author_facet |
Narciso Almeida Vieira Hilton Coimbra Borgo Gisele da Silva Dalben Maria Irene Bachega Paulo Câmara Marques Pereira |
author_sort |
Narciso Almeida Vieira |
title |
Evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty |
title_short |
Evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty |
title_full |
Evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty |
title_fullStr |
Evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty |
title_full_unstemmed |
Evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty |
title_sort |
evaluation of fecal microorganisms of children with cleft palate before and after palatoplasty |
publisher |
Sociedade Brasileira de Microbiologia |
series |
Brazilian Journal of Microbiology |
issn |
1678-4405 |
publishDate |
2013-09-01 |
description |
This study isolated and quantified intestinal bacteria of children with cleft palate before and after palatoplasty. A prospective study was conducted from May 2007 to September 2008 on 18 children with cleft palate, aged one to four years, of both genders, attending a tertiary cleft center in Brazil for palatoplasty, to analyze the effect of surgical palate repair on the concentration of anaerobes Bacteroides sp, Bifidobacterium sp and microaerophiles Lactobacillus sp in feces of infants with cleft palate before and 24 hours after treatment with cefazolin for palatoplasty. There was significant reduction of Lactobacillus sp (p < 0.002), Bacteroides sp (p < 0.001) and Bifidobacterium sp (p = 0.021) after palatoplasty, revealing that surgery and utilization of cefazolin significantly influenced the fecal microbiota comparing collections before and after surgery. However, due to study limitations, it was not possible to conclude that other isolated factors, such as surgical stress, anesthetics and other medications used in palatoplasty might have a significant influence on the microbiota. Considering the important participation of the intestinal microbiota on both local and systemic metabolic and immunological activities of the host, professionals should be attentive to the possible influence of these changes in patients submitted to cleft repair. |
topic |
cleft palate cleft palate/surgery environmental microbiology feces surgery/plastic |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000300026&lng=en&tlng=en |
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