Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers
Abstract Background Brain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the field of MS. In fact, MS is a complex disease and several processes ca...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SpringerOpen
2019-04-01
|
Series: | EJNMMI Radiopharmacy and Chemistry |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s41181-019-0058-3 |
id |
doaj-08ef6260dac3429bb14669b71ab3def3 |
---|---|
record_format |
Article |
spelling |
doaj-08ef6260dac3429bb14669b71ab3def32020-11-25T02:02:35ZengSpringerOpenEJNMMI Radiopharmacy and Chemistry2365-421X2019-04-014112510.1186/s41181-019-0058-3Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracersMatteo Bauckneht0Selene Capitanio1Stefano Raffa2Luca Roccatagliata3Matteo Pardini4Caterina Lapucci5Cecilia Marini6Gianmario Sambuceti7Matilde Inglese8Paolo Gallo9Diego Cecchin10Flavio Nobili11Silvia Morbelli12Nuclear Medicine Unit, IRCCS Ospedale Policlinico San MartinoNuclear Medicine Unit, IRCCS Ospedale Policlinico San MartinoDepartment of Health Sciences (DISSAL), University of GenovaDepartment of Health Sciences (DISSAL), University of GenovaClinical Neurology, Department of Neuroscience (DINOGMI), University of GenoaClinical Neurology, Department of Neuroscience (DINOGMI), University of GenoaNuclear Medicine Unit, IRCCS Ospedale Policlinico San MartinoNuclear Medicine Unit, IRCCS Ospedale Policlinico San MartinoClinical Neurology, Department of Neuroscience (DINOGMI), University of GenoaMultiple Sclerosis Centre of the Veneto Region, Department of Neurosciences DNS, University of PaduaNuclear Medicine Unit, Department of Medicine-DIMED, Padova University HospitalClinical Neurology, Department of Neuroscience (DINOGMI), University of GenoaNuclear Medicine Unit, IRCCS Ospedale Policlinico San MartinoAbstract Background Brain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the field of MS. In fact, MS is a complex disease and several processes can be selected as a target for PET imaging. The use of PET with several different tracers has been mainly evaluated in the research setting to investigate disease pathophysiology (i.e. phenotypes, monitoring of progression) or to explore its use a surrogate end-point in clinical trials. Results We have reviewed PET imaging studies in MS in humans and animal models. Tracers have been grouped according to their pathophysiological targets (ie. tracers for myelin kinetic, neuroinflammation, and neurodegeneration). The emerging clinical indication for brain PET imaging in the differential diagnosis of suspected tumefactive demyelinated plaques as well as the clinical potential provided by PET images in view of the recent introduction of PET/MR technology are also addressed. Conclusion While several preclinical and fewer clinical studies have shown results, full-scale clinical development programs are needed to translate molecular imaging technologies into a clinical reality that could ideally fit into current precision medicine perspectives.http://link.springer.com/article/10.1186/s41181-019-0058-3Multiple sclerosisPositron emission tomographyNeuroinflammationTSPOAmyloidTumefactive multiple sclerosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matteo Bauckneht Selene Capitanio Stefano Raffa Luca Roccatagliata Matteo Pardini Caterina Lapucci Cecilia Marini Gianmario Sambuceti Matilde Inglese Paolo Gallo Diego Cecchin Flavio Nobili Silvia Morbelli |
spellingShingle |
Matteo Bauckneht Selene Capitanio Stefano Raffa Luca Roccatagliata Matteo Pardini Caterina Lapucci Cecilia Marini Gianmario Sambuceti Matilde Inglese Paolo Gallo Diego Cecchin Flavio Nobili Silvia Morbelli Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers EJNMMI Radiopharmacy and Chemistry Multiple sclerosis Positron emission tomography Neuroinflammation TSPO Amyloid Tumefactive multiple sclerosis |
author_facet |
Matteo Bauckneht Selene Capitanio Stefano Raffa Luca Roccatagliata Matteo Pardini Caterina Lapucci Cecilia Marini Gianmario Sambuceti Matilde Inglese Paolo Gallo Diego Cecchin Flavio Nobili Silvia Morbelli |
author_sort |
Matteo Bauckneht |
title |
Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers |
title_short |
Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers |
title_full |
Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers |
title_fullStr |
Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers |
title_full_unstemmed |
Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers |
title_sort |
molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers |
publisher |
SpringerOpen |
series |
EJNMMI Radiopharmacy and Chemistry |
issn |
2365-421X |
publishDate |
2019-04-01 |
description |
Abstract Background Brain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the field of MS. In fact, MS is a complex disease and several processes can be selected as a target for PET imaging. The use of PET with several different tracers has been mainly evaluated in the research setting to investigate disease pathophysiology (i.e. phenotypes, monitoring of progression) or to explore its use a surrogate end-point in clinical trials. Results We have reviewed PET imaging studies in MS in humans and animal models. Tracers have been grouped according to their pathophysiological targets (ie. tracers for myelin kinetic, neuroinflammation, and neurodegeneration). The emerging clinical indication for brain PET imaging in the differential diagnosis of suspected tumefactive demyelinated plaques as well as the clinical potential provided by PET images in view of the recent introduction of PET/MR technology are also addressed. Conclusion While several preclinical and fewer clinical studies have shown results, full-scale clinical development programs are needed to translate molecular imaging technologies into a clinical reality that could ideally fit into current precision medicine perspectives. |
topic |
Multiple sclerosis Positron emission tomography Neuroinflammation TSPO Amyloid Tumefactive multiple sclerosis |
url |
http://link.springer.com/article/10.1186/s41181-019-0058-3 |
work_keys_str_mv |
AT matteobauckneht molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT selenecapitanio molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT stefanoraffa molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT lucaroccatagliata molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT matteopardini molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT caterinalapucci molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT ceciliamarini molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT gianmariosambuceti molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT matildeinglese molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT paologallo molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT diegocecchin molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT flavionobili molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers AT silviamorbelli molecularimagingofmultiplesclerosisfromtheclinicaldemandtonovelradiotracers |
_version_ |
1724952004458971136 |