Value biomarker diagnosis and prediction of acute renal damage in patients with acute coronary syndromes without ST-segment elevation

• Main Authors: S Vladimirovna Avdoshina, S Vadimovna Villevalde, M Alekseevna Efremovtseva, Zh Davidovna Kobalava
• Format: Article
• Language: English
• Published: Peoples’ Friendship University of Russia (RUDN University) 2013-12-01
• Series: RUDN Journal of Medicine
• Subjects: острый коронарный синдром без подъема сегмента ST; острое почечное повреждение; кардиоренальный синдром; терминальный фрагмент предшественника мозгового натрийуретического пептида в сыворотке крови; интерлейкин-18; липокалин ассоциированный с желатиназой нейтрофилов
• Online Access: http://journals.rudn.ru/medicine/article/view/3252
• ISSN: 2313-0245; 2313-0261

Aim: to study the prognostic value of biomarkers (urine neutrophil gelatinase-associated lipocalin (uNGAL), urine interleukin-18 (uIL-18), serum cystatin C (sCysC), serum N-terminal prohormone of brain natriuretic peptide (sNT-proBNP) depending on the acute kidney injury (AKI) in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). 58 patients with NSTE-ACS were examined. Patients with NSTE-ACS and early AKI had higher sCysC, sNT-proBNP, uNGAL and uIL-18 levels than the patients without AKI. No relationship between biomarkers and in-hospital mortality was revealed in patients with cardiorenal syndrome (CRS). AKI — acute kidney injury NSTE-ACS — non-ST-elevation acute coronary syndrome CRS — cardiorenal syndrome NT-proBNP — N-terminal prohormone of Brain Natriuretic Peptide IL-18 — interleukin-18 NGAL — neutrophil gelatinase-associated lipocalin