Mild Diabetes Models and Their Maternal-Fetal Repercussions
The presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reaso...
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doaj-08f6f5494ce84fc891bdd2edd74ff4392020-11-24T23:49:53ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/473575473575Mild Diabetes Models and Their Maternal-Fetal RepercussionsD. C. Damasceno0Y. K. Sinzato1A. Bueno2A. O. Netto3B. Dallaqua4F. Q. Gallego5I. L. Iessi6S. B. Corvino7R. G. Serrano8G. Marini9F. Piculo10I. M. P. Calderon11M. V. C. Rudge12Laboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), 18618-970 Botucatu, SP, BrazilThe presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reasons but also by the many uncontrollable variables. Thus, there is a need to develop appropriate experimental models. The diabetes induced in laboratory animals can be performed by different methods depending on dose, route of administration, and the strain and age of animal used. Many of these studies are carried out in neonatal period or during pregnancy, but the results presented are controversial. So this paper, addresses the review about the different models of mild diabetes induction using streptozotocin in pregnant rats and their repercussions on the maternal and fetal organisms to propose an adequate model for each approached issue.http://dx.doi.org/10.1155/2013/473575 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
D. C. Damasceno Y. K. Sinzato A. Bueno A. O. Netto B. Dallaqua F. Q. Gallego I. L. Iessi S. B. Corvino R. G. Serrano G. Marini F. Piculo I. M. P. Calderon M. V. C. Rudge |
spellingShingle |
D. C. Damasceno Y. K. Sinzato A. Bueno A. O. Netto B. Dallaqua F. Q. Gallego I. L. Iessi S. B. Corvino R. G. Serrano G. Marini F. Piculo I. M. P. Calderon M. V. C. Rudge Mild Diabetes Models and Their Maternal-Fetal Repercussions Journal of Diabetes Research |
author_facet |
D. C. Damasceno Y. K. Sinzato A. Bueno A. O. Netto B. Dallaqua F. Q. Gallego I. L. Iessi S. B. Corvino R. G. Serrano G. Marini F. Piculo I. M. P. Calderon M. V. C. Rudge |
author_sort |
D. C. Damasceno |
title |
Mild Diabetes Models and Their Maternal-Fetal Repercussions |
title_short |
Mild Diabetes Models and Their Maternal-Fetal Repercussions |
title_full |
Mild Diabetes Models and Their Maternal-Fetal Repercussions |
title_fullStr |
Mild Diabetes Models and Their Maternal-Fetal Repercussions |
title_full_unstemmed |
Mild Diabetes Models and Their Maternal-Fetal Repercussions |
title_sort |
mild diabetes models and their maternal-fetal repercussions |
publisher |
Hindawi Limited |
series |
Journal of Diabetes Research |
issn |
2314-6745 2314-6753 |
publishDate |
2013-01-01 |
description |
The presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reasons but also by the many uncontrollable variables. Thus, there is a need to develop appropriate experimental models. The diabetes induced in laboratory animals can be performed by different methods depending on dose, route of administration, and the strain and age of animal used. Many of these studies are carried out in neonatal period or during pregnancy, but the results presented are controversial. So this paper, addresses the review about the different models of mild diabetes induction using streptozotocin in pregnant rats and their repercussions on the maternal and fetal organisms to propose an adequate model for each approached issue. |
url |
http://dx.doi.org/10.1155/2013/473575 |
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