The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Abstract Background There are some limitations of standard chemotherapy for acute leukemia. Vincristine and doxorubicin are commonly used for acute leukemia, but they may induce serious side effects such as cardiomyopathy and neurotoxicity. Furthermore, chemotherapy resistance occurs more and more f...

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Bibliographic Details
Main Authors: Huang-Ju Tu, Yi-Jyun Lin, Min-Wu Chao, Ting-Yi Sung, Yi-Wen Wu, Yi-Ying Chen, Mei-Hsiang Lin, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Clinical Epigenetics
Subjects:
Histone deacetylase 6
Acute leukemia
Combination therapy
Ku70
Microtubule dynamics
Online Access:http://link.springer.com/article/10.1186/s13148-018-0595-8

Internet

http://link.springer.com/article/10.1186/s13148-018-0595-8

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