Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>Infections

Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>Infections

Carbapenem-resistant <i>Enterobacterales </i>(CRE) are included in the list of the most threatening antibiotic resistance microorganisms, being responsible for often insurmountable therapeutic issues, especially in hospitalized patients and immunocompromised individuals and patients in i...

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Main Authors: Corneliu Ovidiu Vrancianu, Elena Georgiana Dobre, Irina Gheorghe, Ilda Barbu, Roxana Elena Cristian, Mariana Carmen Chifiriuc
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Microorganisms
Subjects:
Carbapenem-resistant <i>Enterobacterales </i>(CRE)
multi-drug resistance
novel antibiotics
Online Access:https://www.mdpi.com/2076-2607/9/4/730
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spelling doaj-0900b427f03342b5be2cb6324732466d2021-03-31T23:07:14ZengMDPI AGMicroorganisms2076-26072021-03-01973073010.3390/microorganisms9040730Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>InfectionsCorneliu Ovidiu Vrancianu0Elena Georgiana Dobre1Irina Gheorghe2Ilda Barbu3Roxana Elena Cristian4Mariana Carmen Chifiriuc5Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMicrobiology Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMicrobiology Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMicrobiology Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaMicrobiology Immunology Department, Faculty of Biology, University of Bucharest, 050095 Bucharest, RomaniaCarbapenem-resistant <i>Enterobacterales </i>(CRE) are included in the list of the most threatening antibiotic resistance microorganisms, being responsible for often insurmountable therapeutic issues, especially in hospitalized patients and immunocompromised individuals and patients in intensive care units. The enzymatic resistance to carbapenems is encoded by different β-lactamases belonging to A, B or D Ambler class. Besides compromising the activity of last-resort antibiotics, CRE have spread from the clinical to the environmental sectors, in all geographic regions. The purpose of this review is to present present and future perspectives on CRE-associated infections treatment.https://www.mdpi.com/2076-2607/9/4/730Carbapenem-resistant <i>Enterobacterales </i>(CRE)multi-drug resistancenovel antibiotics
collection DOAJ
language English
format Article
sources DOAJ
author Corneliu Ovidiu Vrancianu
Elena Georgiana Dobre
Irina Gheorghe
Ilda Barbu
Roxana Elena Cristian
Mariana Carmen Chifiriuc
spellingShingle Corneliu Ovidiu Vrancianu
Elena Georgiana Dobre
Irina Gheorghe
Ilda Barbu
Roxana Elena Cristian
Mariana Carmen Chifiriuc
Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>Infections
Microorganisms
Carbapenem-resistant <i>Enterobacterales </i>(CRE)
multi-drug resistance
novel antibiotics
author_facet Corneliu Ovidiu Vrancianu
Elena Georgiana Dobre
Irina Gheorghe
Ilda Barbu
Roxana Elena Cristian
Mariana Carmen Chifiriuc
author_sort Corneliu Ovidiu Vrancianu
title Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>Infections
title_short Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>Infections
title_full Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>Infections
title_fullStr Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>Infections
title_full_unstemmed Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing <i>Enterobacterales </i>Infections
title_sort present and future perspectives on therapeutic options for carbapenemase-producing <i>enterobacterales </i>infections
publisher MDPI AG
series Microorganisms
issn 2076-2607
publishDate 2021-03-01
description Carbapenem-resistant <i>Enterobacterales </i>(CRE) are included in the list of the most threatening antibiotic resistance microorganisms, being responsible for often insurmountable therapeutic issues, especially in hospitalized patients and immunocompromised individuals and patients in intensive care units. The enzymatic resistance to carbapenems is encoded by different β-lactamases belonging to A, B or D Ambler class. Besides compromising the activity of last-resort antibiotics, CRE have spread from the clinical to the environmental sectors, in all geographic regions. The purpose of this review is to present present and future perspectives on CRE-associated infections treatment.
topic Carbapenem-resistant <i>Enterobacterales </i>(CRE)
multi-drug resistance
novel antibiotics
url https://www.mdpi.com/2076-2607/9/4/730
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