A case of dyskeratosis congenita with primary amenorrhea and adenocarcinoma of stomach

• Main Authors: Nandini Chakrabarti, Nilendu Sarma, Chandan Chattopadhyay, Atanu Roy Chowdhuri, Chanchal Das, Salil K Pal
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2011-01-01
• Series: Indian Journal of Dermatology
• Subjects: Adenocarcinoma of stomach; dyskeratosis congenita; primary amenorrhea
• Online Access: http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=5;spage=594;epage=596;aulast=Chakrabarti
• ISSN: 0019-5154; 1998-3611

Dyskeratosis congenita (DC) is a rare disease characterized by hyperpigmentation, nail dystrophy and mucous membrane abnormality. Commonly occurring in males, the patients die young usually due to bone marrow suppression. Malignancies of various descriptions have been reported in this disease, the commonest being solid tumors of head/neck (squamous cell carcinoma). We report the case of a female patient with DC, who presented to us with severe wasting and primary amenorrhea and died of carcinoma stomach in our hospital 3 weeks later.