Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients
Background: Neoadjuvant chemoradiation treatment (CRT) in rectal cancer patients is associated with a reduction in physical capacity, lean mass and increased fatigue. As a countermeasure to these treatment-related adverse effects, we examined the feasibility and preliminary efficacy of a 10-week exe...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2018-09-01
|
Series: | Integrative Cancer Therapies |
Online Access: | https://doi.org/10.1177/1534735418781736 |
id |
doaj-0908509416c54a12953900fa34f67f77 |
---|---|
record_format |
Article |
spelling |
doaj-0908509416c54a12953900fa34f67f772020-11-25T03:24:00ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2018-09-011710.1177/1534735418781736Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer PatientsFavil Singh PhD0Daniel A. Galvão PhD1Robert U. Newton PhD2Nigel A. Spry MBBS, PhD3Michael K. Baker PhD4Dennis R. Taaffe PhD5Edith Cowan University, Perth, Western Australia, AustraliaEdith Cowan University, Perth, Western Australia, AustraliaEdith Cowan University, Perth, Western Australia, AustraliaUniversity of Western Australia, Perth, Western Australia, AustraliaAustralian Catholic University, New South Wales, AustraliaEdith Cowan University, Perth, Western Australia, AustraliaBackground: Neoadjuvant chemoradiation treatment (CRT) in rectal cancer patients is associated with a reduction in physical capacity, lean mass and increased fatigue. As a countermeasure to these treatment-related adverse effects, we examined the feasibility and preliminary efficacy of a 10-week exercise program during CRT. Methods: Ten rectal cancer patients (7 men, aged 27-70 years, body mass index = 26.4 ± 3.8 kg/m 2 ) receiving CRT undertook supervised resistance and aerobic exercise twice weekly. Assessments were undertaken pre- and post-intervention for upper and lower body muscle strength by 1-RM, muscle endurance, physical performance tests, body composition by dual X-ray absorptiometry, quality of life, and fatigue. Results: There was a significant loss in appendicular skeletal muscle (−1.1 kg, P = .012), and fat mass (−0.8 kg, P = .029) following CRT. Despite the loss in skeletal muscle, leg press ( P = .030) and leg extension ( P = .046) strength improved by 27.2% and 22.7%, respectively, and leg press endurance by 76.7% ( P = .007). Changes in strength were accompanied by improved performance ( P < .05) in 6-m fast walking speed (6.9%) and dynamic balance as determined by the 6-m backwards walk (15.5%). There was minimal change in quality of life and fatigue, and no adverse events related to training. Conclusions: Exercise during neoadjuvant CRT appears to be feasible and well tolerated in rectal cancer patients and may enhance physical function while minimizing adverse changes in body composition and cancer-related fatigue. These initial findings need to be confirmed in randomized controlled trials.https://doi.org/10.1177/1534735418781736 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Favil Singh PhD Daniel A. Galvão PhD Robert U. Newton PhD Nigel A. Spry MBBS, PhD Michael K. Baker PhD Dennis R. Taaffe PhD |
spellingShingle |
Favil Singh PhD Daniel A. Galvão PhD Robert U. Newton PhD Nigel A. Spry MBBS, PhD Michael K. Baker PhD Dennis R. Taaffe PhD Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients Integrative Cancer Therapies |
author_facet |
Favil Singh PhD Daniel A. Galvão PhD Robert U. Newton PhD Nigel A. Spry MBBS, PhD Michael K. Baker PhD Dennis R. Taaffe PhD |
author_sort |
Favil Singh PhD |
title |
Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients |
title_short |
Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients |
title_full |
Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients |
title_fullStr |
Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients |
title_full_unstemmed |
Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients |
title_sort |
feasibility and preliminary efficacy of a 10-week resistance and aerobic exercise intervention during neoadjuvant chemoradiation treatment in rectal cancer patients |
publisher |
SAGE Publishing |
series |
Integrative Cancer Therapies |
issn |
1552-695X |
publishDate |
2018-09-01 |
description |
Background: Neoadjuvant chemoradiation treatment (CRT) in rectal cancer patients is associated with a reduction in physical capacity, lean mass and increased fatigue. As a countermeasure to these treatment-related adverse effects, we examined the feasibility and preliminary efficacy of a 10-week exercise program during CRT. Methods: Ten rectal cancer patients (7 men, aged 27-70 years, body mass index = 26.4 ± 3.8 kg/m 2 ) receiving CRT undertook supervised resistance and aerobic exercise twice weekly. Assessments were undertaken pre- and post-intervention for upper and lower body muscle strength by 1-RM, muscle endurance, physical performance tests, body composition by dual X-ray absorptiometry, quality of life, and fatigue. Results: There was a significant loss in appendicular skeletal muscle (−1.1 kg, P = .012), and fat mass (−0.8 kg, P = .029) following CRT. Despite the loss in skeletal muscle, leg press ( P = .030) and leg extension ( P = .046) strength improved by 27.2% and 22.7%, respectively, and leg press endurance by 76.7% ( P = .007). Changes in strength were accompanied by improved performance ( P < .05) in 6-m fast walking speed (6.9%) and dynamic balance as determined by the 6-m backwards walk (15.5%). There was minimal change in quality of life and fatigue, and no adverse events related to training. Conclusions: Exercise during neoadjuvant CRT appears to be feasible and well tolerated in rectal cancer patients and may enhance physical function while minimizing adverse changes in body composition and cancer-related fatigue. These initial findings need to be confirmed in randomized controlled trials. |
url |
https://doi.org/10.1177/1534735418781736 |
work_keys_str_mv |
AT favilsinghphd feasibilityandpreliminaryefficacyofa10weekresistanceandaerobicexerciseinterventionduringneoadjuvantchemoradiationtreatmentinrectalcancerpatients AT danielagalvaophd feasibilityandpreliminaryefficacyofa10weekresistanceandaerobicexerciseinterventionduringneoadjuvantchemoradiationtreatmentinrectalcancerpatients AT robertunewtonphd feasibilityandpreliminaryefficacyofa10weekresistanceandaerobicexerciseinterventionduringneoadjuvantchemoradiationtreatmentinrectalcancerpatients AT nigelasprymbbsphd feasibilityandpreliminaryefficacyofa10weekresistanceandaerobicexerciseinterventionduringneoadjuvantchemoradiationtreatmentinrectalcancerpatients AT michaelkbakerphd feasibilityandpreliminaryefficacyofa10weekresistanceandaerobicexerciseinterventionduringneoadjuvantchemoradiationtreatmentinrectalcancerpatients AT dennisrtaaffephd feasibilityandpreliminaryefficacyofa10weekresistanceandaerobicexerciseinterventionduringneoadjuvantchemoradiationtreatmentinrectalcancerpatients |
_version_ |
1715227417871646720 |