Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes
Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bound lipid species. Here, we investigated associati...
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2021-01-01
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doaj-0917e90c47af468fb367acaaa46793142021-10-09T04:35:16ZengElsevierJournal of Lipid Research0022-22752021-01-0162100119Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetesAmanda M. Fretts0Paul N. Jensen1Andrew N. Hoofnagle2Barbara McKnight3Barbara V. Howard4Jason Umans5Colleen M. Sitlani6David S. Siscovick7Irena B. King8Luc Djousse9Nona Sotoodehnia10Rozenn N. Lemaitre11Department of Epidemiology, University of Washington, Seattle, WA, USA; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; For correspondence: Amanda M. FrettsCardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USADepartment of Medicine, University of Washington, Seattle, WA, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, USACardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Biostatistics, University of Washington, Seattle, WA, USAMedStar Health Research Institute, University of Washington, Hyattsville, MD, USA; Center for Clinical and Translational Science, Georgetown and Howard Universities, Washington, DC, USAMedStar Health Research Institute, University of Washington, Hyattsville, MD, USACardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USANew York Academy of Medicine, New York, NY, USADepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USADepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USACardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USACardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USARecent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bound lipid species. Here, we investigated associations of 15 ceramide (Cer) and SM species (i.e., all sphingolipids, measured with coefficient of variation less than 20%) with incident type 2 diabetes in the Cardiovascular Health Study (n = 3,645), a large cohort study of cardiovascular disease among elderly adults who were followed from 1989 to 2015. Diabetes incidence was defined as fasting glucose ≥126 mg/dl or nonfasting glucose ≥200 mg/dl; reported use of insulin or oral hypoglycemic medication; or documentation of diabetes diagnosis through the Centers for Medicare and Medicaid Services records. Associations of each sphingolipid with incident diabetes were assessed using a Cox proportional hazards regression model. We found that higher circulating levels of Cer with acylated palmitic acid (Cer-16), stearic acid containing Cer (Cer-18), arachidic acid containing Cer (Cer-20), and behenic acid containing Cer (Cer-22) were each associated with a higher risk of diabetes. The hazard ratios for incident diabetes per 1 SD higher log levels of each Cer species were as follows: 1.21 (95% CI: 1.09–1.34) for Cer-16, 1.23 (95% CI: 1.10–1.37) for Cer-18, 1.14 (95% CI: 1.02–1.26) for Cer-20, and 1.18 (95% CI: 1.06–1.32) for Cer-22. In conclusion, higher levels of Cer-16, Cer-18, Cer-20, and Cer-22 were associated with a higher risk of diabetes.http://www.sciencedirect.com/science/article/pii/S0022227521001012epidemiologyelderlyceramidessphingomyelinsdiabetescohort study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amanda M. Fretts Paul N. Jensen Andrew N. Hoofnagle Barbara McKnight Barbara V. Howard Jason Umans Colleen M. Sitlani David S. Siscovick Irena B. King Luc Djousse Nona Sotoodehnia Rozenn N. Lemaitre |
spellingShingle |
Amanda M. Fretts Paul N. Jensen Andrew N. Hoofnagle Barbara McKnight Barbara V. Howard Jason Umans Colleen M. Sitlani David S. Siscovick Irena B. King Luc Djousse Nona Sotoodehnia Rozenn N. Lemaitre Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes Journal of Lipid Research epidemiology elderly ceramides sphingomyelins diabetes cohort study |
author_facet |
Amanda M. Fretts Paul N. Jensen Andrew N. Hoofnagle Barbara McKnight Barbara V. Howard Jason Umans Colleen M. Sitlani David S. Siscovick Irena B. King Luc Djousse Nona Sotoodehnia Rozenn N. Lemaitre |
author_sort |
Amanda M. Fretts |
title |
Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes |
title_short |
Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes |
title_full |
Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes |
title_fullStr |
Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes |
title_full_unstemmed |
Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes |
title_sort |
plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
2021-01-01 |
description |
Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bound lipid species. Here, we investigated associations of 15 ceramide (Cer) and SM species (i.e., all sphingolipids, measured with coefficient of variation less than 20%) with incident type 2 diabetes in the Cardiovascular Health Study (n = 3,645), a large cohort study of cardiovascular disease among elderly adults who were followed from 1989 to 2015. Diabetes incidence was defined as fasting glucose ≥126 mg/dl or nonfasting glucose ≥200 mg/dl; reported use of insulin or oral hypoglycemic medication; or documentation of diabetes diagnosis through the Centers for Medicare and Medicaid Services records. Associations of each sphingolipid with incident diabetes were assessed using a Cox proportional hazards regression model. We found that higher circulating levels of Cer with acylated palmitic acid (Cer-16), stearic acid containing Cer (Cer-18), arachidic acid containing Cer (Cer-20), and behenic acid containing Cer (Cer-22) were each associated with a higher risk of diabetes. The hazard ratios for incident diabetes per 1 SD higher log levels of each Cer species were as follows: 1.21 (95% CI: 1.09–1.34) for Cer-16, 1.23 (95% CI: 1.10–1.37) for Cer-18, 1.14 (95% CI: 1.02–1.26) for Cer-20, and 1.18 (95% CI: 1.06–1.32) for Cer-22. In conclusion, higher levels of Cer-16, Cer-18, Cer-20, and Cer-22 were associated with a higher risk of diabetes. |
topic |
epidemiology elderly ceramides sphingomyelins diabetes cohort study |
url |
http://www.sciencedirect.com/science/article/pii/S0022227521001012 |
work_keys_str_mv |
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