POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C
To study the immune manifestations of the interferon-lambda 3 genepolymorphism in chronic viral hepatitis C, 110 Russian children (54 girls and 56 boys) with chronic HCV infection aged from 3 to 17 years were examined. All children were on combined therapy (pegylated interferon + ribavirin). It was...
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doaj-091d34bd070048fe8df2c75850733e042021-07-28T16:27:47ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282017-09-01624323610.21508/1027-4065-2017-62-4-32-36469POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS CT. B. Sentsova0I. A. Matinyan1I. V. Vorozhko2L. I. Ilyenko3T. V. Strokova4O. O. Chernyak5Federal Research Centre of Nutrition and Biotechnology; Pirogov Russian National Research Medical UniversityFederal Research Centre of Nutrition and BiotechnologyFederal Research Centre of Nutrition and BiotechnologyPirogov Russian National Research Medical UniversityFederal Research Centre of Nutrition and Biotechnology; Pirogov Russian National Research Medical UniversityFederal Research Centre of Nutrition and BiotechnologyTo study the immune manifestations of the interferon-lambda 3 genepolymorphism in chronic viral hepatitis C, 110 Russian children (54 girls and 56 boys) with chronic HCV infection aged from 3 to 17 years were examined. All children were on combined therapy (pegylated interferon + ribavirin). It was found that among the studied polymorphic variants of the IFN-λ 3 gene in children with chronic HCV infection, T allele of the marker rs12979860 is associated with infection and chronization of HCV. The T/T rs12979860 genotype of the IFN-λ3 gene is unfavorable for the course of chronic HCV infection due to low levels of activated T-lymphocytes, intactness of the proinflammatory cytokines TNF-α, IL-6, IL-1α, and interferon-γ inducible protein IP-10. The revealed relation of the polymorphic variants of C/C + C/T locus rs12979860 of INF-λ3 gene with the expression of activated T-lymphocytes discloses the protective nature of these genotypes to the development of chronic HCV infection in children.https://www.ped-perinatology.ru/jour/article/view/523childreninterferon-λ 3gene polymorphismgenotypers12979860rs8099917immunity |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
T. B. Sentsova I. A. Matinyan I. V. Vorozhko L. I. Ilyenko T. V. Strokova O. O. Chernyak |
spellingShingle |
T. B. Sentsova I. A. Matinyan I. V. Vorozhko L. I. Ilyenko T. V. Strokova O. O. Chernyak POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C Rossijskij Vestnik Perinatologii i Pediatrii children interferon-λ 3 gene polymorphism genotype rs12979860 rs8099917 immunity |
author_facet |
T. B. Sentsova I. A. Matinyan I. V. Vorozhko L. I. Ilyenko T. V. Strokova O. O. Chernyak |
author_sort |
T. B. Sentsova |
title |
POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C |
title_short |
POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C |
title_full |
POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C |
title_fullStr |
POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C |
title_full_unstemmed |
POLYMORPHIC VARIANTS OF THE GENE OF INTERFERON LAMBDA 3 AND FEATURES OF IMMUNE RESPONSE IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C |
title_sort |
polymorphic variants of the gene of interferon lambda 3 and features of immune response in children with chronic viral hepatitis c |
publisher |
Ltd. “The National Academy of Pediatric Science and Innovation” |
series |
Rossijskij Vestnik Perinatologii i Pediatrii |
issn |
1027-4065 2500-2228 |
publishDate |
2017-09-01 |
description |
To study the immune manifestations of the interferon-lambda 3 genepolymorphism in chronic viral hepatitis C, 110 Russian children (54 girls and 56 boys) with chronic HCV infection aged from 3 to 17 years were examined. All children were on combined therapy (pegylated interferon + ribavirin). It was found that among the studied polymorphic variants of the IFN-λ 3 gene in children with chronic HCV infection, T allele of the marker rs12979860 is associated with infection and chronization of HCV. The T/T rs12979860 genotype of the IFN-λ3 gene is unfavorable for the course of chronic HCV infection due to low levels of activated T-lymphocytes, intactness of the proinflammatory cytokines TNF-α, IL-6, IL-1α, and interferon-γ inducible protein IP-10. The revealed relation of the polymorphic variants of C/C + C/T locus rs12979860 of INF-λ3 gene with the expression of activated T-lymphocytes discloses the protective nature of these genotypes to the development of chronic HCV infection in children. |
topic |
children interferon-λ 3 gene polymorphism genotype rs12979860 rs8099917 immunity |
url |
https://www.ped-perinatology.ru/jour/article/view/523 |
work_keys_str_mv |
AT tbsentsova polymorphicvariantsofthegeneofinterferonlambda3andfeaturesofimmuneresponseinchildrenwithchronicviralhepatitisc AT iamatinyan polymorphicvariantsofthegeneofinterferonlambda3andfeaturesofimmuneresponseinchildrenwithchronicviralhepatitisc AT ivvorozhko polymorphicvariantsofthegeneofinterferonlambda3andfeaturesofimmuneresponseinchildrenwithchronicviralhepatitisc AT liilyenko polymorphicvariantsofthegeneofinterferonlambda3andfeaturesofimmuneresponseinchildrenwithchronicviralhepatitisc AT tvstrokova polymorphicvariantsofthegeneofinterferonlambda3andfeaturesofimmuneresponseinchildrenwithchronicviralhepatitisc AT oochernyak polymorphicvariantsofthegeneofinterferonlambda3andfeaturesofimmuneresponseinchildrenwithchronicviralhepatitisc |
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