The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia
BackgroundBenzodiazepines have been used preoperatively as part of an anesthesia regimen to attenuate the anxiety of patients. In this study, we aimed to examine the effect of oral triazolam, a short-acting benzodiazepine, on anxiety, sedation, and amnesia.MethodsNinety patients, aged 20–55 years, w...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Korean Society of Anesthesiologists
2017-06-01
|
Series: | Korean Journal of Anesthesiology |
Subjects: | |
Online Access: | http://ekja.org/upload/pdf/kjae-70-292.pdf |
id |
doaj-092f3caba96b4fb4b5563cd8fc85c0b6 |
---|---|
record_format |
Article |
spelling |
doaj-092f3caba96b4fb4b5563cd8fc85c0b62020-11-25T03:44:56ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632017-06-0170329229810.4097/kjae.2017.70.3.2928298The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesiaTaehee Pyeon0Shiyoung Chung1Injae Kim2Seongheon Lee3Seongwook Jeong4Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea.Department of Molecular Medicine, Chonnam National University Medical School, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea.BackgroundBenzodiazepines have been used preoperatively as part of an anesthesia regimen to attenuate the anxiety of patients. In this study, we aimed to examine the effect of oral triazolam, a short-acting benzodiazepine, on anxiety, sedation, and amnesia.MethodsNinety patients, aged 20–55 years, were randomly assigned to receive no premedication, or to receive triazolam 0.25 mg or 0.375 mg 1 h before anesthesia. Anxiety score, sedation score, blood pressure, heart rate and psychomotor performance were measured on the evening before surgery and on the day of surgery. Additional tests of psychomotor performance were performed in the postanesthesia care unit and on the next day of surgery. The occurrence of amnesia, bispectral index (BIS), recovery profiles and patient satisfaction with overall anesthesia care were also evaluated.ResultsChanges in the anxiety and sedation scores on the day of surgery were not significantly different among groups, whereas the increases in systolic blood pressure and heart rate were significantly less in both triazolam groups. The triazolam groups both showed a higher incidence of high satisfaction scores (≥ 2). The two triazolam groups also showed similar outcomes, except for a dose-dependent increase in the number of patients with amnesia and BIS values < 90. Delayed recovery from general anesthesia and psychomotor impairment were not observed in the triazolam groups.ConclusionsTriazolam 0.25 mg or 0.375 mg reduced the hemodynamic changes associated with anxiety, produced potent amnesia, and improved patient satisfaction. We suggest that triazolam can be used effectively as anesthetic premedication in adults.http://ekja.org/upload/pdf/kjae-70-292.pdfamnesiaanxietybenzodiazepinespremedicationtriazolam |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Taehee Pyeon Shiyoung Chung Injae Kim Seongheon Lee Seongwook Jeong |
spellingShingle |
Taehee Pyeon Shiyoung Chung Injae Kim Seongheon Lee Seongwook Jeong The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia Korean Journal of Anesthesiology amnesia anxiety benzodiazepines premedication triazolam |
author_facet |
Taehee Pyeon Shiyoung Chung Injae Kim Seongheon Lee Seongwook Jeong |
author_sort |
Taehee Pyeon |
title |
The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia |
title_short |
The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia |
title_full |
The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia |
title_fullStr |
The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia |
title_full_unstemmed |
The effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia |
title_sort |
effect of triazolam premedication on anxiety, sedation, and amnesia in general anesthesia |
publisher |
Korean Society of Anesthesiologists |
series |
Korean Journal of Anesthesiology |
issn |
2005-6419 2005-7563 |
publishDate |
2017-06-01 |
description |
BackgroundBenzodiazepines have been used preoperatively as part of an anesthesia regimen to attenuate the anxiety of patients. In this study, we aimed to examine the effect of oral triazolam, a short-acting benzodiazepine, on anxiety, sedation, and amnesia.MethodsNinety patients, aged 20–55 years, were randomly assigned to receive no premedication, or to receive triazolam 0.25 mg or 0.375 mg 1 h before anesthesia. Anxiety score, sedation score, blood pressure, heart rate and psychomotor performance were measured on the evening before surgery and on the day of surgery. Additional tests of psychomotor performance were performed in the postanesthesia care unit and on the next day of surgery. The occurrence of amnesia, bispectral index (BIS), recovery profiles and patient satisfaction with overall anesthesia care were also evaluated.ResultsChanges in the anxiety and sedation scores on the day of surgery were not significantly different among groups, whereas the increases in systolic blood pressure and heart rate were significantly less in both triazolam groups. The triazolam groups both showed a higher incidence of high satisfaction scores (≥ 2). The two triazolam groups also showed similar outcomes, except for a dose-dependent increase in the number of patients with amnesia and BIS values < 90. Delayed recovery from general anesthesia and psychomotor impairment were not observed in the triazolam groups.ConclusionsTriazolam 0.25 mg or 0.375 mg reduced the hemodynamic changes associated with anxiety, produced potent amnesia, and improved patient satisfaction. We suggest that triazolam can be used effectively as anesthetic premedication in adults. |
topic |
amnesia anxiety benzodiazepines premedication triazolam |
url |
http://ekja.org/upload/pdf/kjae-70-292.pdf |
work_keys_str_mv |
AT taeheepyeon theeffectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT shiyoungchung theeffectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT injaekim theeffectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT seongheonlee theeffectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT seongwookjeong theeffectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT taeheepyeon effectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT shiyoungchung effectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT injaekim effectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT seongheonlee effectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia AT seongwookjeong effectoftriazolampremedicationonanxietysedationandamnesiaingeneralanesthesia |
_version_ |
1724512514226520064 |