Relevance of hypocapnia to febrile seizures in children
Background: Febrile seizure is the most common type of convulsion in children. However, there are scanty data on the mechanism of its development. The aim of this study was to evaluate the venous blood gas status in children with febrile seizures and to determine whether hypocapnia secondary to hype...
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doaj-093de49100664930ae8f91d9e3f50e362020-11-25T01:52:52ZengSpringerOpenEgyptian Pediatric Association Gazette1110-66382015-09-016339810210.1016/j.epag.2015.08.002Relevance of hypocapnia to febrile seizures in childrenHuda MarzoukBackground: Febrile seizure is the most common type of convulsion in children. However, there are scanty data on the mechanism of its development. The aim of this study was to evaluate the venous blood gas status in children with febrile seizures and to determine whether hypocapnia secondary to hyperthermia-induced hyperventilation was associated with febrile seizures in children. Patients and methods: The study enrolled 43 individuals, twenty-two children with febrile seizures, together with 21 controls (children with febrile illness without seizures). Venous blood gases were determined in the febrile seizure group within 1 h and at 24 h after a seizure attack while, venous blood gases were measured once in the control group within 1 h after a febrile period. Results: There were significant differences in mean blood pH and Pco2 between the febrile seizure and control groups (p < 0.001). There was no significant difference in pH values between the children with complex febrile seizure and those with simple febrile seizure. However, children with complex febrile seizure had significantly lower Pco2 within 1 h of seizure attack than those with simple febrile seizure. In addition, there was a significant correlation between duration of the seizure attack and Pco2 value within 1 h of seizure. Conclusion: The results of the present study confirmed the association between febrile seizure and hypocapnia and that supported the role of hypocapnia in the development of febrile seizures.http://www.sciencedirect.com/science/article/pii/S1110663815000427Febrile seizureBlood gasesHypocapniaComplex febrile seizureEpilepsy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Huda Marzouk |
spellingShingle |
Huda Marzouk Relevance of hypocapnia to febrile seizures in children Egyptian Pediatric Association Gazette Febrile seizure Blood gases Hypocapnia Complex febrile seizure Epilepsy |
author_facet |
Huda Marzouk |
author_sort |
Huda Marzouk |
title |
Relevance of hypocapnia to febrile seizures in children |
title_short |
Relevance of hypocapnia to febrile seizures in children |
title_full |
Relevance of hypocapnia to febrile seizures in children |
title_fullStr |
Relevance of hypocapnia to febrile seizures in children |
title_full_unstemmed |
Relevance of hypocapnia to febrile seizures in children |
title_sort |
relevance of hypocapnia to febrile seizures in children |
publisher |
SpringerOpen |
series |
Egyptian Pediatric Association Gazette |
issn |
1110-6638 |
publishDate |
2015-09-01 |
description |
Background: Febrile seizure is the most common type of convulsion in children. However, there are scanty data on the mechanism of its development. The aim of this study was to evaluate the venous blood gas status in children with febrile seizures and to determine whether hypocapnia secondary to hyperthermia-induced hyperventilation was associated with febrile seizures in children.
Patients and methods: The study enrolled 43 individuals, twenty-two children with febrile seizures, together with 21 controls (children with febrile illness without seizures). Venous blood gases were determined in the febrile seizure group within 1 h and at 24 h after a seizure attack while, venous blood gases were measured once in the control group within 1 h after a febrile period.
Results: There were significant differences in mean blood pH and Pco2 between the febrile seizure and control groups (p < 0.001). There was no significant difference in pH values between the children with complex febrile seizure and those with simple febrile seizure. However, children with complex febrile seizure had significantly lower Pco2 within 1 h of seizure attack than those with simple febrile seizure. In addition, there was a significant correlation between duration of the seizure attack and Pco2 value within 1 h of seizure.
Conclusion: The results of the present study confirmed the association between febrile seizure and hypocapnia and that supported the role of hypocapnia in the development of febrile seizures. |
topic |
Febrile seizure Blood gases Hypocapnia Complex febrile seizure Epilepsy |
url |
http://www.sciencedirect.com/science/article/pii/S1110663815000427 |
work_keys_str_mv |
AT hudamarzouk relevanceofhypocapniatofebrileseizuresinchildren |
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