Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating
Memantine hydrochloride is an uncompetitive N-methyl-D-aspartate (NMDA) antagonist for treatment of moderate-to-severe Alzheimer's disease. Several studies have shown that memantine can significantly correct the binge-like eating behavior in human and animal models. People with overeating behav...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-02-01
|
Series: | Frontiers in Psychiatry |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00015/full |
id |
doaj-09473710f0e444aab6280fa40c89234c |
---|---|
record_format |
Article |
spelling |
doaj-09473710f0e444aab6280fa40c89234c2020-11-25T00:29:28ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-02-011010.3389/fpsyt.2019.00015430957Long-Term NMDAR Antagonism Correlates Weight Loss With Less EatingShi-Ning Deng0Yu-Hua Yan1Tai-Lin Zhu2Bing-Ke Ma3Hui-Ran Fan4Yan-Mei Liu5Wei-Guang Li6Fei Li7Developmental and Behavioral Pediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai, ChinaKey Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai, ChinaKey Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, Shanghai, ChinaDevelopmental and Behavioral Pediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDevelopmental and Behavioral Pediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDevelopmental and Behavioral Pediatric Department and Child Primary Care Department, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMemantine hydrochloride is an uncompetitive N-methyl-D-aspartate (NMDA) antagonist for treatment of moderate-to-severe Alzheimer's disease. Several studies have shown that memantine can significantly correct the binge-like eating behavior in human and animal models. People with overeating behavior are more likely to be obese. Therefore, we suppose that memantine would be a good candidate for the treatment of obesity. In this study, memantine was shown to increase weight loss in obese mice induced by high fat diet. Memantine was shown to decrease food intake without inducing abdominal discomfort and anxiety, suggesting that this compound would be a good candidate drug for obesity control.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00015/fullmemantineobesityweight losshigh fat foodNMDA (N-methy-D-aspartate receptor) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shi-Ning Deng Yu-Hua Yan Tai-Lin Zhu Bing-Ke Ma Hui-Ran Fan Yan-Mei Liu Wei-Guang Li Fei Li |
spellingShingle |
Shi-Ning Deng Yu-Hua Yan Tai-Lin Zhu Bing-Ke Ma Hui-Ran Fan Yan-Mei Liu Wei-Guang Li Fei Li Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating Frontiers in Psychiatry memantine obesity weight loss high fat food NMDA (N-methy-D-aspartate receptor) |
author_facet |
Shi-Ning Deng Yu-Hua Yan Tai-Lin Zhu Bing-Ke Ma Hui-Ran Fan Yan-Mei Liu Wei-Guang Li Fei Li |
author_sort |
Shi-Ning Deng |
title |
Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating |
title_short |
Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating |
title_full |
Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating |
title_fullStr |
Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating |
title_full_unstemmed |
Long-Term NMDAR Antagonism Correlates Weight Loss With Less Eating |
title_sort |
long-term nmdar antagonism correlates weight loss with less eating |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2019-02-01 |
description |
Memantine hydrochloride is an uncompetitive N-methyl-D-aspartate (NMDA) antagonist for treatment of moderate-to-severe Alzheimer's disease. Several studies have shown that memantine can significantly correct the binge-like eating behavior in human and animal models. People with overeating behavior are more likely to be obese. Therefore, we suppose that memantine would be a good candidate for the treatment of obesity. In this study, memantine was shown to increase weight loss in obese mice induced by high fat diet. Memantine was shown to decrease food intake without inducing abdominal discomfort and anxiety, suggesting that this compound would be a good candidate drug for obesity control. |
topic |
memantine obesity weight loss high fat food NMDA (N-methy-D-aspartate receptor) |
url |
https://www.frontiersin.org/article/10.3389/fpsyt.2019.00015/full |
work_keys_str_mv |
AT shiningdeng longtermnmdarantagonismcorrelatesweightlosswithlesseating AT yuhuayan longtermnmdarantagonismcorrelatesweightlosswithlesseating AT tailinzhu longtermnmdarantagonismcorrelatesweightlosswithlesseating AT bingkema longtermnmdarantagonismcorrelatesweightlosswithlesseating AT huiranfan longtermnmdarantagonismcorrelatesweightlosswithlesseating AT yanmeiliu longtermnmdarantagonismcorrelatesweightlosswithlesseating AT weiguangli longtermnmdarantagonismcorrelatesweightlosswithlesseating AT feili longtermnmdarantagonismcorrelatesweightlosswithlesseating |
_version_ |
1725331136513572864 |