| Summary: | <div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p class="s5"><span class="s6"><span class="bumpedFont15">Abstract</span></span></p><p class="s5"><span class="s6"><span class="bumpedFont15">B</span></span><span class="s6"><span class="bumpedFont15">ackground</span></span><span class="s6"><span class="bumpedFont15">: </span></span><span class="s7"><span class="bumpedFont15">So far</span></span><span class="s7"><span class="bumpedFont15">, many studies </span></span><span class="s7"><span class="bumpedFont15">have been performed</span></span><span class="s7"><span class="bumpedFont15"> to determine the optimal dose and regimen of</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">tranexamic acid to reduce </span></span><span class="s7"><span class="bumpedFont15">preoperative and postoperative blood loss in primary total knee</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">arthroplasty. In th</span></span><span class="s7"><span class="bumpedFont15">e present</span></span><span class="s7"><span class="bumpedFont15"> study, two different methods of administration (bolus and infusion)</span></span><span class="s7"><span class="bumpedFont15">,</span></span><span class="s7"><span class="bumpedFont15"> were</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">compared.</span></span></p><p class="s5"><span class="s6"><span class="bumpedFont15">Materials and Methods</span></span><span class="s6"><span class="bumpedFont15">: </span></span><span class="s7"><span class="bumpedFont15">Forty patients were randomized in</span></span><span class="s7"><span class="bumpedFont15"> the </span></span><span class="s7"><span class="bumpedFont15">two groups</span></span><span class="s7"><span class="bumpedFont15"> (A and B)</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">of 20 patient</span></span><span class="s7"><span class="bumpedFont15">s each</span></span><span class="s7"><span class="bumpedFont15">. A</span></span><span class="s7"><span class="bumpedFont15">ll patients received 500 mg</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">tranexamic acid before </span></span><span class="s7"><span class="bumpedFont15">inflation of </span></span><span class="s7"><span class="bumpedFont15">tourniquet. Group A (mean age</span></span><span class="s7"><span class="bumpedFont15">, </span></span><span class="s7"><span class="bumpedFont15">64± 6.1 years) received 500 mg tranexamic acid </span></span><span class="s7"><span class="bumpedFont15">10 </span></span><span class="s7"><span class="bumpedFont15">minutes before</span></span><span class="s7"><span class="bumpedFont15"> loosening of</span></span><span class="s7"><span class="bumpedFont15"> tourniquet and</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">group B (</span></span><span class="s7"><span class="bumpedFont15">mean age, </span></span><span class="s7"><span class="bumpedFont15">63.5 ± 7.7 years) received 500 mg</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">tranexamic acid</span></span><span class="s7"><span class="bumpedFont15"> through</span></span><span class="s7"><span class="bumpedFont15"> IV infusion during 6 hours from the</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">time of tourniquet loosening (total dose of TA</span></span><span class="s7"><span class="bumpedFont15">,</span></span><span class="s7"><span class="bumpedFont15"> 1 g in both groups). Intraoperative blood loss,</span></span><span class="s7"><span class="bumpedFont15">postoperative drainage (in 6 and 12 hours), blood transfusion (in 48 hours), </span></span><span class="s7"><span class="bumpedFont15">and decrease in </span></span><span class="s7"><span class="bumpedFont15">hematocrit</span></span><span class="s7"><span class="bumpedFont15"> and</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">hemoglobin</span></span><span class="s7"><span class="bumpedFont15"> (6 and 12 hours later)</span></span><span class="s7"><span class="bumpedFont15">,</span></span><span class="s7"><span class="bumpedFont15"> were compared between</span></span><span class="s7"><span class="bumpedFont15"> the</span></span><span class="s7"><span class="bumpedFont15"> two groups.</span></span></p><p class="s5"><span class="s6"><span class="bumpedFont15">R</span></span><span class="s6"><span class="bumpedFont15">esults</span></span><span class="s6"><span class="bumpedFont15">: </span></span><span class="s7"><span class="bumpedFont15">The patients in group B had </span></span><span class="s7"><span class="bumpedFont15">lower </span></span><span class="s7"><span class="bumpedFont15">intra- and postoperative </span></span><span class="s7"><span class="bumpedFont15">blood loss </span></span><span class="s7"><span class="bumpedFont15">in 6 and 12</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">hours and also had </span></span><span class="s7"><span class="bumpedFont15">lower decrease in </span></span><span class="s7"><span class="bumpedFont15">hemoglobin</span></span><span class="s7"><span class="bumpedFont15">,</span></span><span class="s7"><span class="bumpedFont15"> and </span></span><span class="s7"><span class="bumpedFont15">their </span></span><span class="s7"><span class="bumpedFont15">packed cell transfusion rate was significantly</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">lower compared to</span></span><span class="s7"><span class="bumpedFont15"> the</span></span><span class="s7"><span class="bumpedFont15"> group A.</span></span></p><p class="s5"><span class="s6"><span class="bumpedFont15">C</span></span><span class="s6"><span class="bumpedFont15">onclusion</span></span><span class="s6"><span class="bumpedFont15">: </span></span><span class="s7"><span class="bumpedFont15">The findings of this</span></span><span class="s7"><span class="bumpedFont15"> study </span></span><span class="s7"><span class="bumpedFont15">indicated </span></span><span class="s7"><span class="bumpedFont15">that infusion administration of tranexamic acid in</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">primary total knee arthroplasty</span></span><span class="s7"><span class="bumpedFont15">,</span></span><span class="s7"><span class="bumpedFont15"> was more effective </span></span><span class="s7"><span class="bumpedFont15">in the reduction of</span></span><span class="s7"><span class="bumpedFont15"> perioperative blood loss </span></span><span class="s7"><span class="bumpedFont15">as well as</span></span><span class="s7"><span class="bumpedFont15"> </span></span><span class="s7"><span class="bumpedFont15">need</span></span><span class="s7"><span class="bumpedFont15"> for blood transfusion in 48 hours.</span></span></p></div></div></div></div>
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