Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop...
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doaj-09587f72118e41a7ac10e904cfb9b3d72021-07-23T13:56:39ZengMDPI AGMolecules1420-30492021-07-01264274427410.3390/molecules26144274Electrophilically Activated Nitroalkanes in Synthesis of 3,4-DihydroquinozalinesAlexander V. Aksenov0Igor Yu. Grishin1Nicolai A. Aksenov2Vladimir V. Malyuga3Dmitrii A. Aksenov4Mezvah A. Nobi5Michael Rubin6Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USADepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaNitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.https://www.mdpi.com/1420-3049/26/14/4274nitroalkanesheterocyclic compoundsquinozalinesannulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexander V. Aksenov Igor Yu. Grishin Nicolai A. Aksenov Vladimir V. Malyuga Dmitrii A. Aksenov Mezvah A. Nobi Michael Rubin |
spellingShingle |
Alexander V. Aksenov Igor Yu. Grishin Nicolai A. Aksenov Vladimir V. Malyuga Dmitrii A. Aksenov Mezvah A. Nobi Michael Rubin Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines Molecules nitroalkanes heterocyclic compounds quinozalines annulation |
author_facet |
Alexander V. Aksenov Igor Yu. Grishin Nicolai A. Aksenov Vladimir V. Malyuga Dmitrii A. Aksenov Mezvah A. Nobi Michael Rubin |
author_sort |
Alexander V. Aksenov |
title |
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines |
title_short |
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines |
title_full |
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines |
title_fullStr |
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines |
title_full_unstemmed |
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines |
title_sort |
electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-07-01 |
description |
Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines. |
topic |
nitroalkanes heterocyclic compounds quinozalines annulation |
url |
https://www.mdpi.com/1420-3049/26/14/4274 |
work_keys_str_mv |
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