Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines

Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop...

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Main Authors:	Alexander V. Aksenov, Igor Yu. Grishin, Nicolai A. Aksenov, Vladimir V. Malyuga, Dmitrii A. Aksenov, Mezvah A. Nobi, Michael Rubin
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Molecules
Subjects:	nitroalkanes heterocyclic compounds quinozalines annulation
Online Access:	https://www.mdpi.com/1420-3049/26/14/4274

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spelling	doaj-09587f72118e41a7ac10e904cfb9b3d72021-07-23T13:56:39ZengMDPI AGMolecules1420-30492021-07-01264274427410.3390/molecules26144274Electrophilically Activated Nitroalkanes in Synthesis of 3,4-DihydroquinozalinesAlexander V. Aksenov0Igor Yu. Grishin1Nicolai A. Aksenov2Vladimir V. Malyuga3Dmitrii A. Aksenov4Mezvah A. Nobi5Michael Rubin6Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaDepartment of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USADepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, RussiaNitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.https://www.mdpi.com/1420-3049/26/14/4274nitroalkanesheterocyclic compoundsquinozalinesannulation
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Alexander V. Aksenov Igor Yu. Grishin Nicolai A. Aksenov Vladimir V. Malyuga Dmitrii A. Aksenov Mezvah A. Nobi Michael Rubin
spellingShingle	Alexander V. Aksenov Igor Yu. Grishin Nicolai A. Aksenov Vladimir V. Malyuga Dmitrii A. Aksenov Mezvah A. Nobi Michael Rubin Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines Molecules nitroalkanes heterocyclic compounds quinozalines annulation
author_facet	Alexander V. Aksenov Igor Yu. Grishin Nicolai A. Aksenov Vladimir V. Malyuga Dmitrii A. Aksenov Mezvah A. Nobi Michael Rubin
author_sort	Alexander V. Aksenov
title	Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_short	Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_full	Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_fullStr	Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_full_unstemmed	Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines
title_sort	electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-07-01
description	Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.
topic	nitroalkanes heterocyclic compounds quinozalines annulation
url	https://www.mdpi.com/1420-3049/26/14/4274
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Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines

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