Austrian Syndrome: a report of an exceptionally rare and deadly syndrome

• Main Authors: Gustavo Nobre de Jesus, Tânia Carvalho, Alexandre Caldeira, Susana M. Fernandes
• Format: Article
• Language: Portuguese
• Published: Universidade de São Paulo 2020-12-01
• Series: Medicina
• Subjects: Streptococcus pneumoniae; Meningitis; Pneumonia; Endocarditis
• Online Access: https://www.revistas.usp.br/rmrp/article/view/166259

Austrian Syndrome is the rare combination of a triad of endocarditis, meningitis, and pneumonia in the context of pneumococcal infection. Due to the involvement of several anatomical sites, the Austrian syndrome has a high mortality. Importantly, endocarditis is usually not considered during pneumococcal infection. We present a case of Austrian syndrome in a previously healthy 67-year-old woman. She featured with mental state alteration, respiratory failure, and shock, and was diagnosed with ceftriaxone-sensitive pneumococcal bacteremia, meningitis, and pneumonia. A transesophageal echocardiogram revealed vegetation of the mitral valve. Despite an improvement in her medical condition, she remained in a coma and died due to neurological complications. Even though the major cause of mortality in Austrian syndrome is cardiac involvement, meningitis is also linked with high morbidity and eventually death. We emphasize the relevance of an early diagnosis of the triad in order to decrease the very high mortality associated with this syndrome.