Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides

Structural basis of mammalian high-mannose N-glycan processing by human gut Bacteroides

Human gut bacteria depolymerize glycans into their sugar components, which otherwise cannot be processed by their host. Here, the authors characterise the endo-β-N-acetylglucosaminidase EndoBT-3987 from the Gram-negative symbiont Bacteroides thetaiotaomicron and present the crystal structures of lig...

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Bibliographic Details
Main Authors: Beatriz Trastoy, Jonathan J. Du, Erik H. Klontz, Chao Li, Javier O. Cifuente, Lai-Xi Wang, Eric J. Sundberg, Marcelo E. Guerin
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14754-7
Description
Summary:Human gut bacteria depolymerize glycans into their sugar components, which otherwise cannot be processed by their host. Here, the authors characterise the endo-β-N-acetylglucosaminidase EndoBT-3987 from the Gram-negative symbiont Bacteroides thetaiotaomicron and present the crystal structures of ligand-free EndoBT-3987, a substrate bound complex and product complexes.
ISSN:2041-1723

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