Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis
Primary progressive aphasia (PPA) brings together neurodegenerative pathologies whose main characteristic is to start with a progressive language disorder. PPA diagnosis is often delayed in non-specialised clinical settings. With the technologies’ development, new writing parameters can be extracted...
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doaj-096c7dab80ca45fba1ddba3387ae09db2021-09-25T23:48:39ZengMDPI AGBrain Sciences2076-34252021-09-01111198119810.3390/brainsci11091198Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential DiagnosisAlexandra Plonka0Aurélie Mouton1Joël Macoir2Thi-Mai Tran3Alexandre Derremaux4Philippe Robert5Valeria Manera6Auriane Gros7Département d’Orthophonie de Nice, Faculté de Médecine, Université Côte d’Azur, 06000 Nice, FranceDépartement d’Orthophonie de Nice, Faculté de Médecine, Université Côte d’Azur, 06000 Nice, FranceDépartement de Réadaptation, Faculté de Médecine, Université Laval, Québec, QC G1V 0A6, CanadaLaboratoire STL, UMR 8163, Département d‘Orthophonie, UFR3S, Université de Lille, 59000 Lille, FranceLaboratoire CoBTeK (Cognition Behaviour Technology), Université Côte d’Azur, 06000 Nice, FranceDépartement d’Orthophonie de Nice, Faculté de Médecine, Université Côte d’Azur, 06000 Nice, FranceLaboratoire CoBTeK (Cognition Behaviour Technology), Université Côte d’Azur, 06000 Nice, FranceDépartement d’Orthophonie de Nice, Faculté de Médecine, Université Côte d’Azur, 06000 Nice, FrancePrimary progressive aphasia (PPA) brings together neurodegenerative pathologies whose main characteristic is to start with a progressive language disorder. PPA diagnosis is often delayed in non-specialised clinical settings. With the technologies’ development, new writing parameters can be extracted, such as the writing pressure on a touch pad. Despite some studies having highlighted differences between patients with typical Alzheimer’s disease (AD) and healthy controls, writing parameters in PPAs are understudied. The objective was to verify if the writing pressure in different linguistic and non-linguistic tasks can differentiate patients with PPA from patients with AD and healthy subjects. Patients with PPA (n = 32), patients with AD (n = 22) and healthy controls (n = 26) were included in this study. They performed a set of handwriting tasks on an iPad<sup>®</sup> digital tablet, including linguistic, cognitive non-linguistic, and non-cognitive non-linguistic tasks. Average and maximum writing pressures were extracted for each task. We found significant differences in writing pressure, between healthy controls and patients with PPA, and between patients with PPA and AD. However, the classification of performances was dependent on the nature of the tasks. These results suggest that measuring writing pressure in graphical tasks may improve the early diagnosis of PPA, and the differential diagnosis between PPA and AD.https://www.mdpi.com/2076-3425/11/9/1198primary progressive aphasiaAlzheimer’s diseasegraphical markersgraphical parameterswriting pressuredifferential diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alexandra Plonka Aurélie Mouton Joël Macoir Thi-Mai Tran Alexandre Derremaux Philippe Robert Valeria Manera Auriane Gros |
spellingShingle |
Alexandra Plonka Aurélie Mouton Joël Macoir Thi-Mai Tran Alexandre Derremaux Philippe Robert Valeria Manera Auriane Gros Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis Brain Sciences primary progressive aphasia Alzheimer’s disease graphical markers graphical parameters writing pressure differential diagnosis |
author_facet |
Alexandra Plonka Aurélie Mouton Joël Macoir Thi-Mai Tran Alexandre Derremaux Philippe Robert Valeria Manera Auriane Gros |
author_sort |
Alexandra Plonka |
title |
Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis |
title_short |
Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis |
title_full |
Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis |
title_fullStr |
Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis |
title_full_unstemmed |
Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis |
title_sort |
primary progressive aphasia: use of graphical markers for an early and differential diagnosis |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2021-09-01 |
description |
Primary progressive aphasia (PPA) brings together neurodegenerative pathologies whose main characteristic is to start with a progressive language disorder. PPA diagnosis is often delayed in non-specialised clinical settings. With the technologies’ development, new writing parameters can be extracted, such as the writing pressure on a touch pad. Despite some studies having highlighted differences between patients with typical Alzheimer’s disease (AD) and healthy controls, writing parameters in PPAs are understudied. The objective was to verify if the writing pressure in different linguistic and non-linguistic tasks can differentiate patients with PPA from patients with AD and healthy subjects. Patients with PPA (n = 32), patients with AD (n = 22) and healthy controls (n = 26) were included in this study. They performed a set of handwriting tasks on an iPad<sup>®</sup> digital tablet, including linguistic, cognitive non-linguistic, and non-cognitive non-linguistic tasks. Average and maximum writing pressures were extracted for each task. We found significant differences in writing pressure, between healthy controls and patients with PPA, and between patients with PPA and AD. However, the classification of performances was dependent on the nature of the tasks. These results suggest that measuring writing pressure in graphical tasks may improve the early diagnosis of PPA, and the differential diagnosis between PPA and AD. |
topic |
primary progressive aphasia Alzheimer’s disease graphical markers graphical parameters writing pressure differential diagnosis |
url |
https://www.mdpi.com/2076-3425/11/9/1198 |
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