Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer

Background: Environmental phenols, compounds used widely in personal care and consumer products, are known endocrine disruptors. Few epidemiologic studies have examined the association of phenol biomarkers with breast cancer incidence and, to our knowledge, none have considered associations with mor...

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Main Authors: Humberto Parada, Jr, Marilie D. Gammon, Hope L. Ettore, Jia Chen, Antonia M. Calafat, Alfred I. Neugut, Regina M. Santella, Mary S. Wolff, Susan L. Teitelbaum
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Environment International
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412019306506
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author Humberto Parada, Jr
Marilie D. Gammon
Hope L. Ettore
Jia Chen
Antonia M. Calafat
Alfred I. Neugut
Regina M. Santella
Mary S. Wolff
Susan L. Teitelbaum
spellingShingle Humberto Parada, Jr
Marilie D. Gammon
Hope L. Ettore
Jia Chen
Antonia M. Calafat
Alfred I. Neugut
Regina M. Santella
Mary S. Wolff
Susan L. Teitelbaum
Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer
Environment International
author_facet Humberto Parada, Jr
Marilie D. Gammon
Hope L. Ettore
Jia Chen
Antonia M. Calafat
Alfred I. Neugut
Regina M. Santella
Mary S. Wolff
Susan L. Teitelbaum
author_sort Humberto Parada, Jr
title Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer
title_short Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer
title_full Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer
title_fullStr Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer
title_full_unstemmed Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer
title_sort urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancer
publisher Elsevier
series Environment International
issn 0160-4120
publishDate 2019-09-01
description Background: Environmental phenols, compounds used widely in personal care and consumer products, are known endocrine disruptors. Few epidemiologic studies have examined the association of phenol biomarkers with breast cancer incidence and, to our knowledge, none have considered associations with mortality following breast cancer. We examined seven urinary phenol biomarkers in association with breast cancer incidence and subsequent mortality, and examined effect measure modification by body mass index (BMI). Methods: Participants included 711 women with breast cancer and 598 women without breast cancer who were interviewed for the population-based Long Island Breast Cancer Study Project. Among women with breast cancer, phenol biomarkers were quantified in spot urine samples collected on average within three months of a first diagnosis of primary in situ or invasive breast cancer in 1996–1997. Women with breast cancer were monitored for vital status using the National Death Index. After a median follow-up of 17.6 years, we identified 271 deaths, including 98 deaths from breast cancer. We examined creatinine-corrected phenol concentrations and the sum of parabens (Σparabens) in association with breast cancer incidence using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs), and with mortality using Cox regression to estimate hazard ratios (HRs) and 95% CIs. We evaluated multiplicative effect measure modification using cross-product terms in nested models. Results: The highest (vs lowest) quintiles of urinary methylparaben, propylparaben, and Σparabens were associated with risk of breast cancer with ORs ranging from 1.31 to 1.50. Methylparaben, propylparaben, and Σparabens were also associated with all-cause mortality HRs ranging from 0.68 to 0.77. Associations for breast cancer incidence were more pronounced among women with BMI < 25.0 kg/m2 than among women with BMI ≥ 25.0 kg/m2; however, associations for mortality were more pronounced among women with BMI ≥ 25 kg/m2 than among women with BMI < 25 kg/m2. Conclusions: Select parabens may have differential associations with risk of developing breast cancer and mortality following breast cancer. Keywords: Breast cancer, Environmental phenols, Incidence, Mortality, Personal care products, Parabens, BPA, Triclosan
url http://www.sciencedirect.com/science/article/pii/S0160412019306506
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spelling doaj-0975e3cddea346a8ac6d0deb48b867b82020-11-25T01:44:34ZengElsevierEnvironment International0160-41202019-09-01130Urinary concentrations of environmental phenols and their associations with breast cancer incidence and mortality following breast cancerHumberto Parada, Jr0Marilie D. Gammon1Hope L. Ettore2Jia Chen3Antonia M. Calafat4Alfred I. Neugut5Regina M. Santella6Mary S. Wolff7Susan L. Teitelbaum8Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, CA, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA; Corresponding author at: San Diego State University, School of Public Health, Division of Epidemiology and Biostatistics, Hardy Tower Room #168, 5500 Campanile Drive, San Diego, CA 92182-4162, USA.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USADivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, CA, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USACenters for Disease Control and Prevention, Atlanta, GA, USADepartment of Medicine, Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USADepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USABackground: Environmental phenols, compounds used widely in personal care and consumer products, are known endocrine disruptors. Few epidemiologic studies have examined the association of phenol biomarkers with breast cancer incidence and, to our knowledge, none have considered associations with mortality following breast cancer. We examined seven urinary phenol biomarkers in association with breast cancer incidence and subsequent mortality, and examined effect measure modification by body mass index (BMI). Methods: Participants included 711 women with breast cancer and 598 women without breast cancer who were interviewed for the population-based Long Island Breast Cancer Study Project. Among women with breast cancer, phenol biomarkers were quantified in spot urine samples collected on average within three months of a first diagnosis of primary in situ or invasive breast cancer in 1996–1997. Women with breast cancer were monitored for vital status using the National Death Index. After a median follow-up of 17.6 years, we identified 271 deaths, including 98 deaths from breast cancer. We examined creatinine-corrected phenol concentrations and the sum of parabens (Σparabens) in association with breast cancer incidence using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs), and with mortality using Cox regression to estimate hazard ratios (HRs) and 95% CIs. We evaluated multiplicative effect measure modification using cross-product terms in nested models. Results: The highest (vs lowest) quintiles of urinary methylparaben, propylparaben, and Σparabens were associated with risk of breast cancer with ORs ranging from 1.31 to 1.50. Methylparaben, propylparaben, and Σparabens were also associated with all-cause mortality HRs ranging from 0.68 to 0.77. Associations for breast cancer incidence were more pronounced among women with BMI < 25.0 kg/m2 than among women with BMI ≥ 25.0 kg/m2; however, associations for mortality were more pronounced among women with BMI ≥ 25 kg/m2 than among women with BMI < 25 kg/m2. Conclusions: Select parabens may have differential associations with risk of developing breast cancer and mortality following breast cancer. Keywords: Breast cancer, Environmental phenols, Incidence, Mortality, Personal care products, Parabens, BPA, Triclosanhttp://www.sciencedirect.com/science/article/pii/S0160412019306506