Regulator of cullins-1 (ROC1) negatively regulates the Gli2 regulator SUFU to activate the hedgehog pathway in bladder cancer

Regulator of cullins-1 (ROC1) negatively regulates the Gli2 regulator SUFU to activate the hedgehog pathway in bladder cancer

Abstract Background The regulator of cullins-1 (ROC1) is an essential subunit in the cullin-RING ligase (CRL) protein complex and has been shown to be critical in bladder cancer cell survival and progression. This study aimed to explore the molecular mechanism of ROC1 action in the malignant progres...

Full description

Bibliographic Details
Main Authors: W. Wang, J. Qiu, P. Qu, H. Chen, J. Lan, L. Li, M. Gu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cancer Cell International
Subjects:
Bladder cancer
ROC1
Sonic hedgehog signaling
SUFU
Gli2
Online Access:https://doi.org/10.1186/s12935-021-01775-5

Similar Items

Similar Items