Immunoregulation by Taenia crassiceps and Its Antigens

Taenia crassiceps is a cestode parasite of rodents (in its larval stage) and canids (in its adult stage) that can also parasitize immunocompromised humans. We have studied the immune response elicited by this helminth and its antigens in mice and human cells, and have discovered that they have a str...

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Main Authors: Alberto N. Peón, Arlett Espinoza-Jiménez, Luis I. Terrazas
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/498583
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spelling doaj-097921c518a64e3080056228e139971e2020-11-24T22:26:31ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/498583498583Immunoregulation by Taenia crassiceps and Its AntigensAlberto N. Peón0Arlett Espinoza-Jiménez1Luis I. Terrazas2Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Avenida De los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Avenida De los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoUnidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Avenida De los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, MexicoTaenia crassiceps is a cestode parasite of rodents (in its larval stage) and canids (in its adult stage) that can also parasitize immunocompromised humans. We have studied the immune response elicited by this helminth and its antigens in mice and human cells, and have discovered that they have a strong capacity to induce chronic Th2-type responses that are primarily characterized by high levels of Th2 cytokines, low proliferative responses in lymphocytes, an immature and LPS-tolerogenic profile in dendritic cells, the recruitment of myeloid-derived suppressor cells and, specially, alternatively activated macrophages. We also have utilized the immunoregulatory capabilities of this helminth to successfully modulate autoimmune responses and the outcome of other infectious diseases. In the present paper, we review the work of others and ourselves with regard to the immune response induced by T. crassiceps and its antigens, and we compare the advances in our understanding of this parasitic infection model with the knowledge that has been obtained from other selected models.http://dx.doi.org/10.1155/2013/498583
collection DOAJ
language English
format Article
sources DOAJ
author Alberto N. Peón
Arlett Espinoza-Jiménez
Luis I. Terrazas
spellingShingle Alberto N. Peón
Arlett Espinoza-Jiménez
Luis I. Terrazas
Immunoregulation by Taenia crassiceps and Its Antigens
BioMed Research International
author_facet Alberto N. Peón
Arlett Espinoza-Jiménez
Luis I. Terrazas
author_sort Alberto N. Peón
title Immunoregulation by Taenia crassiceps and Its Antigens
title_short Immunoregulation by Taenia crassiceps and Its Antigens
title_full Immunoregulation by Taenia crassiceps and Its Antigens
title_fullStr Immunoregulation by Taenia crassiceps and Its Antigens
title_full_unstemmed Immunoregulation by Taenia crassiceps and Its Antigens
title_sort immunoregulation by taenia crassiceps and its antigens
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description Taenia crassiceps is a cestode parasite of rodents (in its larval stage) and canids (in its adult stage) that can also parasitize immunocompromised humans. We have studied the immune response elicited by this helminth and its antigens in mice and human cells, and have discovered that they have a strong capacity to induce chronic Th2-type responses that are primarily characterized by high levels of Th2 cytokines, low proliferative responses in lymphocytes, an immature and LPS-tolerogenic profile in dendritic cells, the recruitment of myeloid-derived suppressor cells and, specially, alternatively activated macrophages. We also have utilized the immunoregulatory capabilities of this helminth to successfully modulate autoimmune responses and the outcome of other infectious diseases. In the present paper, we review the work of others and ourselves with regard to the immune response induced by T. crassiceps and its antigens, and we compare the advances in our understanding of this parasitic infection model with the knowledge that has been obtained from other selected models.
url http://dx.doi.org/10.1155/2013/498583
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AT arlettespinozajimenez immunoregulationbytaeniacrassicepsanditsantigens
AT luisiterrazas immunoregulationbytaeniacrassicepsanditsantigens
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