Role of Polyphenols and Other Phytochemicals on Molecular Signaling
Optimized nutrition through supplementation of diet with plant derived phytochemicals has attracted significant attention to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. These phytonutrients alone or in combination with others are b...
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Online Access: | http://dx.doi.org/10.1155/2015/504253 |
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doaj-09887d22e14848cea5eb1b614366802e2020-11-24T21:59:04ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942015-01-01201510.1155/2015/504253504253Role of Polyphenols and Other Phytochemicals on Molecular SignalingSwapna Upadhyay0Madhulika Dixit1Laboratory of Vascular Biology, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences and Bioengineering Building, Indian Institute of Technology, Madras, Chennai, Tamil Nadu 600036, IndiaLaboratory of Vascular Biology, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences and Bioengineering Building, Indian Institute of Technology, Madras, Chennai, Tamil Nadu 600036, IndiaOptimized nutrition through supplementation of diet with plant derived phytochemicals has attracted significant attention to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. These phytonutrients alone or in combination with others are believed to impart beneficial effects and play pivotal role in metabolic abnormalities such as dyslipidemia, insulin resistance, hypertension, glucose intolerance, systemic inflammation, and oxidative stress. Epidemiological and preclinical studies demonstrated that fruits, vegetables, and beverages rich in carotenoids, isoflavones, phytoestrogens, and phytosterols delay the onset of atherosclerosis or act as a chemoprotective agent by interacting with the underlying pathomechanisms. Phytochemicals exert their beneficial effects either by reducing the circulating levels of cholesterol or by inhibiting lipid oxidation, while others exhibit anti-inflammatory and antiplatelet activities. Additionally, they reduce neointimal thickening by inhibiting proliferation of smooth muscle cells and also improve endothelium dependent vasorelaxation by modulating bioavailability of nitric-oxide and voltage-gated ion channels. However, detailed and profound knowledge on specific molecular targets of each phytochemical is very important to ensure safe use of these active compounds as a therapeutic agent. Thus, this paper reviews the active antioxidative, antiproliferative, anti-inflammatory, or antiangiogenesis role of various phytochemicals for prevention of chronic diseases.http://dx.doi.org/10.1155/2015/504253 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Swapna Upadhyay Madhulika Dixit |
spellingShingle |
Swapna Upadhyay Madhulika Dixit Role of Polyphenols and Other Phytochemicals on Molecular Signaling Oxidative Medicine and Cellular Longevity |
author_facet |
Swapna Upadhyay Madhulika Dixit |
author_sort |
Swapna Upadhyay |
title |
Role of Polyphenols and Other Phytochemicals on Molecular Signaling |
title_short |
Role of Polyphenols and Other Phytochemicals on Molecular Signaling |
title_full |
Role of Polyphenols and Other Phytochemicals on Molecular Signaling |
title_fullStr |
Role of Polyphenols and Other Phytochemicals on Molecular Signaling |
title_full_unstemmed |
Role of Polyphenols and Other Phytochemicals on Molecular Signaling |
title_sort |
role of polyphenols and other phytochemicals on molecular signaling |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2015-01-01 |
description |
Optimized nutrition through supplementation of diet with plant derived phytochemicals has attracted significant attention to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. These phytonutrients alone or in combination with others are believed to impart beneficial effects and play pivotal role in metabolic abnormalities such as dyslipidemia, insulin resistance, hypertension, glucose intolerance, systemic inflammation, and oxidative stress. Epidemiological and preclinical studies demonstrated that fruits, vegetables, and beverages rich in carotenoids, isoflavones, phytoestrogens, and phytosterols delay the onset of atherosclerosis or act as a chemoprotective agent by interacting with the underlying pathomechanisms. Phytochemicals exert their beneficial effects either by reducing the circulating levels of cholesterol or by inhibiting lipid oxidation, while others exhibit anti-inflammatory and antiplatelet activities. Additionally, they reduce neointimal thickening by inhibiting proliferation of smooth muscle cells and also improve endothelium dependent vasorelaxation by modulating bioavailability of nitric-oxide and voltage-gated ion channels. However, detailed and profound knowledge on specific molecular targets of each phytochemical is very important to ensure safe use of these active compounds as a therapeutic agent. Thus, this paper reviews the active antioxidative, antiproliferative, anti-inflammatory, or antiangiogenesis role of various phytochemicals for prevention of chronic diseases. |
url |
http://dx.doi.org/10.1155/2015/504253 |
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