Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls
Heterotopic cardiac xenotransplantation in the intra-abdominal position has been studied extensively in a pig-to-baboon model to define the optimal donor genetics and immunosuppressive regimen to prevent xenograft rejection. Extensive investigation using this model is a necessary stepping stone towa...
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcvm.2019.00095/full |
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doaj-0993d03b2ad6476d96e26c338a01de292020-11-25T00:37:46ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2019-07-01610.3389/fcvm.2019.00095454449Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and PitfallsLaura DiChiacchio0Avneesh K. Singh1Joshua L. Chan2Nicole M. Shockcor3Tianshu Zhang4Billeta G. Lewis5David Ayares6Philip Corcoran7Keith A. Horvath8Muhammad M. Mohiuddin9Department of Surgery, University of Maryland Medical Center, Baltimore, MD, United StatesDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, United StatesNational Heart, Lung, Blood Institute, National Institute of Health, Bethesda, MD, United StatesDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, United StatesDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, United StatesDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, United StatesRevivicor, Inc., Blacksburg, VA, United StatesNational Heart, Lung, Blood Institute, National Institute of Health, Bethesda, MD, United StatesNational Heart, Lung, Blood Institute, National Institute of Health, Bethesda, MD, United StatesDepartment of Surgery, University of Maryland Medical Center, Baltimore, MD, United StatesHeterotopic cardiac xenotransplantation in the intra-abdominal position has been studied extensively in a pig-to-baboon model to define the optimal donor genetics and immunosuppressive regimen to prevent xenograft rejection. Extensive investigation using this model is a necessary stepping stone toward the development of a life-supporting animal model, with the ultimate goal of demonstrating suitability for clinical cardiac xenotransplantation trials. Aspects of surgical technique, pre- and post-operative care, graft monitoring, and minimization of infectious risk have all required refinement and optimization of heterotopic cardiac xenotransplantation over time. This review details non-immunologic obstacles relevant to this model described by our group and in the literature, as well as strategies that have been developed to address these specific challenges.https://www.frontiersin.org/article/10.3389/fcvm.2019.00095/fullxenotransplantxenograftcardiacpigbaboonabdominal |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Laura DiChiacchio Avneesh K. Singh Joshua L. Chan Nicole M. Shockcor Tianshu Zhang Billeta G. Lewis David Ayares Philip Corcoran Keith A. Horvath Muhammad M. Mohiuddin |
| spellingShingle |
Laura DiChiacchio Avneesh K. Singh Joshua L. Chan Nicole M. Shockcor Tianshu Zhang Billeta G. Lewis David Ayares Philip Corcoran Keith A. Horvath Muhammad M. Mohiuddin Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls Frontiers in Cardiovascular Medicine xenotransplant xenograft cardiac pig baboon abdominal |
| author_facet |
Laura DiChiacchio Avneesh K. Singh Joshua L. Chan Nicole M. Shockcor Tianshu Zhang Billeta G. Lewis David Ayares Philip Corcoran Keith A. Horvath Muhammad M. Mohiuddin |
| author_sort |
Laura DiChiacchio |
| title |
Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls |
| title_short |
Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls |
| title_full |
Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls |
| title_fullStr |
Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls |
| title_full_unstemmed |
Intra-Abdominal Heterotopic Cardiac Xenotransplantation: Pearls and Pitfalls |
| title_sort |
intra-abdominal heterotopic cardiac xenotransplantation: pearls and pitfalls |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cardiovascular Medicine |
| issn |
2297-055X |
| publishDate |
2019-07-01 |
| description |
Heterotopic cardiac xenotransplantation in the intra-abdominal position has been studied extensively in a pig-to-baboon model to define the optimal donor genetics and immunosuppressive regimen to prevent xenograft rejection. Extensive investigation using this model is a necessary stepping stone toward the development of a life-supporting animal model, with the ultimate goal of demonstrating suitability for clinical cardiac xenotransplantation trials. Aspects of surgical technique, pre- and post-operative care, graft monitoring, and minimization of infectious risk have all required refinement and optimization of heterotopic cardiac xenotransplantation over time. This review details non-immunologic obstacles relevant to this model described by our group and in the literature, as well as strategies that have been developed to address these specific challenges. |
| topic |
xenotransplant xenograft cardiac pig baboon abdominal |
| url |
https://www.frontiersin.org/article/10.3389/fcvm.2019.00095/full |
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