OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS

Objective. The objective of this initial phase of the study is to retrospectively screen rheumatoid arthritis (RA) phenotype characteristics associated with osteoporosis. Methods. The study included all RA patients who randomly came to the university rheumatology department between January and Jul...

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Main Authors: Catalina Raluca Nuta, Claudiu C. Popescu, Denisa Predeteanu, Ruxandra Ionescu
Format: Article
Language:English
Published: Amaltea Medical Publishing House 2018-09-01
Series:Romanian Journal of Rheumatology
Subjects:
Online Access:https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2018-Nr.3/RJR_2018_3_Art-03.pdf
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spelling doaj-099580d4147f43749c05e7dde50e2dc12021-09-02T18:48:16ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862018-09-0127311412110.37897/RJR.2018.3.3OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITISCatalina Raluca Nuta0Claudiu C. Popescu1Denisa Predeteanu2Ruxandra Ionescu3Ana Aslan National Institute of Gerontology and Geriatrics, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestCarol Davila University of Medicine and Pharmacy, Bucharest; Dr. Ion Stoia Clinical Centre for Rheumatic Diseases, BucharestCarol Davila University of Medicine and Pharmacy, Bucharest; Sf. Maria Clinical Hospital, BucharestCarol Davila University of Medicine and Pharmacy, Bucharest; Sf. Maria Clinical Hospital, BucharestObjective. The objective of this initial phase of the study is to retrospectively screen rheumatoid arthritis (RA) phenotype characteristics associated with osteoporosis. Methods. The study included all RA patients who randomly came to the university rheumatology department between January and July 2018. Demographic data, anthropometric data, RA-specific variables, osteoporosis data and comorbidities were collected retrospectively and cross-sectionally from the first (and most frequently the only) observation sheet of each patient within the study timeframe. Correlations and comparison were analyzed using appropriate non-parametric tests, all of the reported being significant (p<0.05). Results. The sample included 149 RA patients (60.8 years mean age; 81.2% women), 40 (26.8%) of which had osteoporosis and 31 (20.8%) were obese. Compared to RA patients without osteoporosis, RA patients with osteoporosis were significantly older (56.0 respectively 71.0 years) and had: lower body mass index (BMI; 23.8 kg/m2 respectively 29.6 kg/m2 ), longer disease duration (11.0 respectively 17.0 years), higher prevalence of rural dwelling (prevalence ratio – PR=2.46), smoking (PR=3.71), inflammation (PR=1.35), anti-citrullinated protein antibody positivity (PR=1.51), glucocorticoids (PR=1.85) and carotid artery disease (PR=3.01), but a lower prevalence of obesity (PR=3.43). Lumbar bone mineral density was significantly correlated with BMI (rho=0.294) and with rheumatoid factor titers (rho=0.311), controlling for age, gender and disease duration. Conclusions. BMI-defined obesity seems to be associated with a lower prevalence of osteoporosis among RA patients, while disease severity (treatment with glucocorticoids, inflammation and ACPA positivity) is associated with a higher prevalence of osteoporosis. Gain of adipose tissue and loss of bone tissue seem to be antagonistic and parallel body composition alterations in RA.https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2018-Nr.3/RJR_2018_3_Art-03.pdfrheumatoid arthritisosteoporosisobesity
collection DOAJ
language English
format Article
sources DOAJ
author Catalina Raluca Nuta
Claudiu C. Popescu
Denisa Predeteanu
Ruxandra Ionescu
spellingShingle Catalina Raluca Nuta
Claudiu C. Popescu
Denisa Predeteanu
Ruxandra Ionescu
OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS
Romanian Journal of Rheumatology
rheumatoid arthritis
osteoporosis
obesity
author_facet Catalina Raluca Nuta
Claudiu C. Popescu
Denisa Predeteanu
Ruxandra Ionescu
author_sort Catalina Raluca Nuta
title OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS
title_short OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS
title_full OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS
title_fullStr OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS
title_full_unstemmed OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS
title_sort osteoporosis is associated with a lower prevalence of body mass index-defined obesity in rheumatoid arthritis
publisher Amaltea Medical Publishing House
series Romanian Journal of Rheumatology
issn 1843-0791
2069-6086
publishDate 2018-09-01
description Objective. The objective of this initial phase of the study is to retrospectively screen rheumatoid arthritis (RA) phenotype characteristics associated with osteoporosis. Methods. The study included all RA patients who randomly came to the university rheumatology department between January and July 2018. Demographic data, anthropometric data, RA-specific variables, osteoporosis data and comorbidities were collected retrospectively and cross-sectionally from the first (and most frequently the only) observation sheet of each patient within the study timeframe. Correlations and comparison were analyzed using appropriate non-parametric tests, all of the reported being significant (p<0.05). Results. The sample included 149 RA patients (60.8 years mean age; 81.2% women), 40 (26.8%) of which had osteoporosis and 31 (20.8%) were obese. Compared to RA patients without osteoporosis, RA patients with osteoporosis were significantly older (56.0 respectively 71.0 years) and had: lower body mass index (BMI; 23.8 kg/m2 respectively 29.6 kg/m2 ), longer disease duration (11.0 respectively 17.0 years), higher prevalence of rural dwelling (prevalence ratio – PR=2.46), smoking (PR=3.71), inflammation (PR=1.35), anti-citrullinated protein antibody positivity (PR=1.51), glucocorticoids (PR=1.85) and carotid artery disease (PR=3.01), but a lower prevalence of obesity (PR=3.43). Lumbar bone mineral density was significantly correlated with BMI (rho=0.294) and with rheumatoid factor titers (rho=0.311), controlling for age, gender and disease duration. Conclusions. BMI-defined obesity seems to be associated with a lower prevalence of osteoporosis among RA patients, while disease severity (treatment with glucocorticoids, inflammation and ACPA positivity) is associated with a higher prevalence of osteoporosis. Gain of adipose tissue and loss of bone tissue seem to be antagonistic and parallel body composition alterations in RA.
topic rheumatoid arthritis
osteoporosis
obesity
url https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2018-Nr.3/RJR_2018_3_Art-03.pdf
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AT denisapredeteanu osteoporosisisassociatedwithalowerprevalenceofbodymassindexdefinedobesityinrheumatoidarthritis
AT ruxandraionescu osteoporosisisassociatedwithalowerprevalenceofbodymassindexdefinedobesityinrheumatoidarthritis
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