Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China.
To explore the epidemic history of HIV-1 CRF01_AE in China, 408 fragments of gag gene sequences of CRF01_AE sampled in 2002-2010 were determined from different geographical regions and risk populations in China. Phylogenetic analysis indicates that the CRF01_AE sequences can be grouped into four clu...
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doaj-09998dc2c1e845cb99a2a74253d33f702020-11-25T02:15:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5423810.1371/journal.pone.0054238Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China.Jingrong YeRuolei XinShuangqing YuLishi BaiWeishi WangTingchen WuXueli SuHongyan LuXinghuo PangHong YanXia FengXiong HeYi ZengTo explore the epidemic history of HIV-1 CRF01_AE in China, 408 fragments of gag gene sequences of CRF01_AE sampled in 2002-2010 were determined from different geographical regions and risk populations in China. Phylogenetic analysis indicates that the CRF01_AE sequences can be grouped into four clusters, suggesting that at least four genetically independent CRF01_AE descendants are circulating in China, of which two were closely related to the isolates from Thailand and Vietnam. Cluster 1 has the most extensive distribution in China. In North China, cluster 1 and cluster 4 were mainly transmitted through homosexuality.The real substance of the recent HIV-1 epidemic in men who have sex with men(MSM) of North China is a rapid spread of CRF01_AE, or rather two distinctive natives CRF01_AE.The time of the most recent common ancestor (tMRCA) of four CRF01_AE clusters ranged from the years 1990.9 to 2003.8 in different regions of China. This is the first phylogenetic and temporal dynamics study of HIV-1 CRF01_AE in China.http://europepmc.org/articles/PMC3554705?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jingrong Ye Ruolei Xin Shuangqing Yu Lishi Bai Weishi Wang Tingchen Wu Xueli Su Hongyan Lu Xinghuo Pang Hong Yan Xia Feng Xiong He Yi Zeng |
spellingShingle |
Jingrong Ye Ruolei Xin Shuangqing Yu Lishi Bai Weishi Wang Tingchen Wu Xueli Su Hongyan Lu Xinghuo Pang Hong Yan Xia Feng Xiong He Yi Zeng Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China. PLoS ONE |
author_facet |
Jingrong Ye Ruolei Xin Shuangqing Yu Lishi Bai Weishi Wang Tingchen Wu Xueli Su Hongyan Lu Xinghuo Pang Hong Yan Xia Feng Xiong He Yi Zeng |
author_sort |
Jingrong Ye |
title |
Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China. |
title_short |
Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China. |
title_full |
Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China. |
title_fullStr |
Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China. |
title_full_unstemmed |
Phylogenetic and temporal dynamics of human immunodeficiency virus type 1 CRF01_AE in China. |
title_sort |
phylogenetic and temporal dynamics of human immunodeficiency virus type 1 crf01_ae in china. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
To explore the epidemic history of HIV-1 CRF01_AE in China, 408 fragments of gag gene sequences of CRF01_AE sampled in 2002-2010 were determined from different geographical regions and risk populations in China. Phylogenetic analysis indicates that the CRF01_AE sequences can be grouped into four clusters, suggesting that at least four genetically independent CRF01_AE descendants are circulating in China, of which two were closely related to the isolates from Thailand and Vietnam. Cluster 1 has the most extensive distribution in China. In North China, cluster 1 and cluster 4 were mainly transmitted through homosexuality.The real substance of the recent HIV-1 epidemic in men who have sex with men(MSM) of North China is a rapid spread of CRF01_AE, or rather two distinctive natives CRF01_AE.The time of the most recent common ancestor (tMRCA) of four CRF01_AE clusters ranged from the years 1990.9 to 2003.8 in different regions of China. This is the first phylogenetic and temporal dynamics study of HIV-1 CRF01_AE in China. |
url |
http://europepmc.org/articles/PMC3554705?pdf=render |
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