The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome
ABSTRACT Objective We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). Subjects and methods In 180...
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Brazilian Society of Endocrinology and Metabolism
2017-09-01
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doaj-099f6750ef0949fe967a7862a16de8b62020-11-24T20:48:03ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922017-09-0161651552310.1590/2359-3997000000289S2359-39972017000600515The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndromeOmur TabakGonul SimsekFusun ErdenenVolkan SozerTuna HasogluRemise GelisgenEsma AltunogluCuneyt MuderrisogluAbdulhalim SenyigitHafize UzunABSTRACT Objective We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). Subjects and methods In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits. Results While fasting plasma hsCRP, PTX-3, IL-33, irisin, RBP-4 concentrations were higher, adiponectin levels were lower in patients with MetS than in controls. A correlation analysis revealed that plasma irisin levels were positively associated with MetS components such as waist circumference and waist-hip ratio, low density lipoprotein (LDL) and markers of systemic inflammation such as PTX-3, hsCRP, uric acid, and RBP-4. Adiponectin levels were negatively associated with waist circumference, waist-hip ratio, PTX-3 and LDL. Conclusions Although the precise mechanisms are still unclear, irisin, RBP-4, adiponectin and PTX-3 are hallmarks of the MetS, which is related to low-grade inflammation. It is conceivable that irisin and adiponectin might contribute to the development of MetS and may also represent novel MetS components. Future clinical studies are needed to confirm and extend these data.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000600515&lng=en&tlng=enMetabolic syndromehigh sensitivity C-reactive proteinpentraxin-3interleukin-33irisinretinol binding protein-4adiponectin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Omur Tabak Gonul Simsek Fusun Erdenen Volkan Sozer Tuna Hasoglu Remise Gelisgen Esma Altunoglu Cuneyt Muderrisoglu Abdulhalim Senyigit Hafize Uzun |
spellingShingle |
Omur Tabak Gonul Simsek Fusun Erdenen Volkan Sozer Tuna Hasoglu Remise Gelisgen Esma Altunoglu Cuneyt Muderrisoglu Abdulhalim Senyigit Hafize Uzun The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome Archives of Endocrinology and Metabolism Metabolic syndrome high sensitivity C-reactive protein pentraxin-3 interleukin-33 irisin retinol binding protein-4 adiponectin |
author_facet |
Omur Tabak Gonul Simsek Fusun Erdenen Volkan Sozer Tuna Hasoglu Remise Gelisgen Esma Altunoglu Cuneyt Muderrisoglu Abdulhalim Senyigit Hafize Uzun |
author_sort |
Omur Tabak |
title |
The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome |
title_short |
The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome |
title_full |
The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome |
title_fullStr |
The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome |
title_full_unstemmed |
The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome |
title_sort |
relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome |
publisher |
Brazilian Society of Endocrinology and Metabolism |
series |
Archives of Endocrinology and Metabolism |
issn |
2359-4292 |
publishDate |
2017-09-01 |
description |
ABSTRACT Objective We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). Subjects and methods In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits. Results While fasting plasma hsCRP, PTX-3, IL-33, irisin, RBP-4 concentrations were higher, adiponectin levels were lower in patients with MetS than in controls. A correlation analysis revealed that plasma irisin levels were positively associated with MetS components such as waist circumference and waist-hip ratio, low density lipoprotein (LDL) and markers of systemic inflammation such as PTX-3, hsCRP, uric acid, and RBP-4. Adiponectin levels were negatively associated with waist circumference, waist-hip ratio, PTX-3 and LDL. Conclusions Although the precise mechanisms are still unclear, irisin, RBP-4, adiponectin and PTX-3 are hallmarks of the MetS, which is related to low-grade inflammation. It is conceivable that irisin and adiponectin might contribute to the development of MetS and may also represent novel MetS components. Future clinical studies are needed to confirm and extend these data. |
topic |
Metabolic syndrome high sensitivity C-reactive protein pentraxin-3 interleukin-33 irisin retinol binding protein-4 adiponectin |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000600515&lng=en&tlng=en |
work_keys_str_mv |
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