Optimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentation
To develop the effective control method for fed-batch culture of cyclosporin A production, we chose fructose, L-valine and (NH4)2HPO4 as feeding nutrients and compared their productivities in relation to different concentrations. The feeding rate of three kinds of feeding materials was controlled...
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University of Belgrade, University of Novi Sad
2011-01-01
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Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103907D.pdf |
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doaj-09a0bed875c0458a8d02d419824c54d32020-11-24T21:01:32ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642011-01-0163390791410.2298/ABS1103907DOptimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentationDong HuijunJiang JunyunYan TongshunZhao JunjieTo develop the effective control method for fed-batch culture of cyclosporin A production, we chose fructose, L-valine and (NH4)2HPO4 as feeding nutrients and compared their productivities in relation to different concentrations. The feeding rate of three kinds of feeding materials was controlled to maintain the suitable residual concentration. The fed-batch fermentation results indicated that the optimal concentrations of fructose, L-valine and (NH4)2HPO4 were about 20 g/L, 0.5 g/L and 0.6 g/L for cyclosporin A production, respectively. The cultivation of Beauveria nivea could produce cyclosporin A up to 6.2 g/L for 240 hrs through a continuous feeding-rate-controlled-batch process under the optimal feeding conditions.http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103907D.pdfcyclosporin Afed-batch fermentationBeauveria nivea |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong Huijun Jiang Junyun Yan Tongshun Zhao Junjie |
spellingShingle |
Dong Huijun Jiang Junyun Yan Tongshun Zhao Junjie Optimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentation Archives of Biological Sciences cyclosporin A fed-batch fermentation Beauveria nivea |
author_facet |
Dong Huijun Jiang Junyun Yan Tongshun Zhao Junjie |
author_sort |
Dong Huijun |
title |
Optimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentation |
title_short |
Optimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentation |
title_full |
Optimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentation |
title_fullStr |
Optimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentation |
title_full_unstemmed |
Optimization of cyclosporin A production by Beauveria nivea in continuous fed-batch fermentation |
title_sort |
optimization of cyclosporin a production by beauveria nivea in continuous fed-batch fermentation |
publisher |
University of Belgrade, University of Novi Sad |
series |
Archives of Biological Sciences |
issn |
0354-4664 |
publishDate |
2011-01-01 |
description |
To develop the effective control method for fed-batch culture of cyclosporin A production, we chose fructose, L-valine and (NH4)2HPO4 as feeding nutrients and compared their productivities in relation to different concentrations. The feeding rate of three kinds of feeding materials was controlled to maintain the suitable residual concentration. The fed-batch fermentation results indicated that the optimal concentrations of fructose, L-valine and (NH4)2HPO4 were about 20 g/L, 0.5 g/L and 0.6 g/L for cyclosporin A production, respectively. The cultivation of Beauveria nivea could produce cyclosporin A up to 6.2 g/L for 240 hrs through a continuous feeding-rate-controlled-batch process under the optimal feeding conditions. |
topic |
cyclosporin A fed-batch fermentation Beauveria nivea |
url |
http://www.doiserbia.nb.rs/img/doi/0354-4664/2011/0354-46641103907D.pdf |
work_keys_str_mv |
AT donghuijun optimizationofcyclosporinaproductionbybeauverianiveaincontinuousfedbatchfermentation AT jiangjunyun optimizationofcyclosporinaproductionbybeauverianiveaincontinuousfedbatchfermentation AT yantongshun optimizationofcyclosporinaproductionbybeauverianiveaincontinuousfedbatchfermentation AT zhaojunjie optimizationofcyclosporinaproductionbybeauverianiveaincontinuousfedbatchfermentation |
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1716777681721229312 |