TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs

TRPV4 mediates cell damage induced by hyperphysiological compression and regulates COX2/PGE2 in intervertebral discs

Abstract Background Aberrant mechanical loading of the spine causes intervertebral disc (IVD) degeneration and low back pain. Current therapies do not target the mediators of the underlying mechanosensing and mechanotransduction pathways, as these are poorly understood. This study investigated the r...

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Bibliographic Details
Main Authors: Elena Cambria, Sally Heusser, Ariane C. Scheuren, Wai Kit Tam, Agnieszka A. Karol, Wolfgang Hitzl, Victor Y. Leung, Ralph Müller, Stephen J. Ferguson, Karin Wuertz‐Kozak
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:JOR Spine
Subjects:
dynamic compression
low back pain
mechanobiology
mechanosensing
mechanotransduction
transient receptor potential channels
Online Access:https://doi.org/10.1002/jsp2.1149

Internet

https://doi.org/10.1002/jsp2.1149

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