Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis
The article presents the data of the randomized clinical trial of 80 young patients with destructive pulmonary tuberculosis for various methods of TB drugs injection. Particular attention is paid to the role of parenteral drug delivery. The work demonstrated that newly diagnosed patients with destru...
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Scientific Сentre for Family Health and Human Reproduction Problems
2016-09-01
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doaj-09a3c19ea30741b082b27b1f619646e02021-08-17T13:52:55ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962016-09-0115353910.12737/23347274Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosisI. A. Morozov0V. Y. Mishin1A. V. Mishina2A. L. Sobkin3V. A. Guseva4D. D. Petrov5Moscow State University of Medicine and Dentistry named after A.I. Evdokimov; Tuberculosis Clinical Hospital N 3 named after G.A. ZakharinMoscow State University of Medicine and Dentistry named after A.I. EvdokimovMoscow State University of Medicine and Dentistry named after A.I. Evdokimov; Tuberculosis Clinical Hospital N 3 named after G.A. ZakharinTuberculosis Clinical Hospital N 3 named after G.A. ZakharinTuberculosis Clinical Hospital N 3 named after G.A. ZakharinMoscow State University of Medicine and Dentistry named after A.I. Evdokimov; Tuberculosis Clinical Hospital N 3 named after G.A. ZakharinThe article presents the data of the randomized clinical trial of 80 young patients with destructive pulmonary tuberculosis for various methods of TB drugs injection. Particular attention is paid to the role of parenteral drug delivery. The work demonstrated that newly diagnosed patients with destructive pulmonary tuberculosis of younger age the most optimal and effective is parenteral injection of injectable forms of TB drugs, allowing to halt bacterioexcretion for 3 months in 92.5 % of cases and to close cavities in the lungs in 80 %. In newly diagnosed patients with destructive pulmonary tuberculosis of young age oral use of tablets and of TB drugs is not effective enough, allowing to achieve 3 months cessation of bacterial isolation in 85.2 % of cases and to close cavities in the lungs in 42.5 %. Undesirable side reactions to parenteral administration of injectable forms of TB drugs were detected in 17.5 % of patients and to separate oral tablet forms - in 20 %, fatal reactions were observed in 5 % of cases of drug delivery regardless of method.https://www.actabiomedica.ru/jour/article/view/274tuberculosisdrug-resistant of mycobacterium tuberculosistb drugsmethods of drug injection |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
I. A. Morozov V. Y. Mishin A. V. Mishina A. L. Sobkin V. A. Guseva D. D. Petrov |
spellingShingle |
I. A. Morozov V. Y. Mishin A. V. Mishina A. L. Sobkin V. A. Guseva D. D. Petrov Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis Acta Biomedica Scientifica tuberculosis drug-resistant of mycobacterium tuberculosis tb drugs methods of drug injection |
author_facet |
I. A. Morozov V. Y. Mishin A. V. Mishina A. L. Sobkin V. A. Guseva D. D. Petrov |
author_sort |
I. A. Morozov |
title |
Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis |
title_short |
Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis |
title_full |
Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis |
title_fullStr |
Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis |
title_full_unstemmed |
Efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis |
title_sort |
efficiency of various methods of injection of antituberculosis agents in young patients with destructive pulmonary tuberculosis |
publisher |
Scientific Сentre for Family Health and Human Reproduction Problems |
series |
Acta Biomedica Scientifica |
issn |
2541-9420 2587-9596 |
publishDate |
2016-09-01 |
description |
The article presents the data of the randomized clinical trial of 80 young patients with destructive pulmonary tuberculosis for various methods of TB drugs injection. Particular attention is paid to the role of parenteral drug delivery. The work demonstrated that newly diagnosed patients with destructive pulmonary tuberculosis of younger age the most optimal and effective is parenteral injection of injectable forms of TB drugs, allowing to halt bacterioexcretion for 3 months in 92.5 % of cases and to close cavities in the lungs in 80 %. In newly diagnosed patients with destructive pulmonary tuberculosis of young age oral use of tablets and of TB drugs is not effective enough, allowing to achieve 3 months cessation of bacterial isolation in 85.2 % of cases and to close cavities in the lungs in 42.5 %. Undesirable side reactions to parenteral administration of injectable forms of TB drugs were detected in 17.5 % of patients and to separate oral tablet forms - in 20 %, fatal reactions were observed in 5 % of cases of drug delivery regardless of method. |
topic |
tuberculosis drug-resistant of mycobacterium tuberculosis tb drugs methods of drug injection |
url |
https://www.actabiomedica.ru/jour/article/view/274 |
work_keys_str_mv |
AT iamorozov efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT vymishin efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT avmishina efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT alsobkin efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT vaguseva efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis AT ddpetrov efficiencyofvariousmethodsofinjectionofantituberculosisagentsinyoungpatientswithdestructivepulmonarytuberculosis |
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1721204500172111872 |