Salmonella Coiled-Coil- and TIR-Containing TcpS Evades the Innate Immune System and Subdues Inflammation

Salmonella Coiled-Coil- and TIR-Containing TcpS Evades the Innate Immune System and Subdues Inflammation

Summary: Toll-like receptors (TLRs) activate innate immunity via interactions between their Toll/interleukin-1 (IL-1) receptor (TIR) domain and downstream adaptor proteins. Here we report that Salmonella Enteritidis produces a secreted protein (TcpS) that contains both a TIR domain and a coiled-coil...

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Bibliographic Details
Main Authors: Dan Xiong, Li Song, Shizhong Geng, Yang Jiao, Xiaohui Zhou, Hongqin Song, Xilong Kang, Yi Zhou, Xiulong Xu, Jun Sun, Zhiming Pan, Xinan Jiao
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719308216

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