Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22339-1 |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Pradeep Natarajan Akhil Pampana Sarah E. Graham Sanni E. Ruotsalainen James A. Perry Paul S. de Vries Jai G. Broome James P. Pirruccello Michael C. Honigberg Krishna Aragam Brooke Wolford Jennifer A. Brody Lucinda Antonacci-Fulton Moscati Arden Stella Aslibekyan Themistocles L. Assimes Christie M. Ballantyne Lawrence F. Bielak Joshua C. Bis Brian E. Cade Ron Do Harsha Doddapaneni Leslie S. Emery Yi-Jen Hung Marguerite R. Irvin Alyna T. Khan Leslie Lange Jiwon Lee Rozenn N. Lemaitre Lisa W. Martin Ginger Metcalf May E. Montasser Jee-Young Moon Donna Muzny Jeffrey R. O’Connell Nicholette D. Palmer Juan M. Peralta Patricia A. Peyser Adrienne M. Stilp Michael Tsai Fei Fei Wang Daniel E. Weeks Lisa R. Yanek James G. Wilson Goncalo Abecasis Donna K. Arnett Lewis C. Becker John Blangero Eric Boerwinkle Donald W. Bowden Yi-Cheng Chang Yii-Der I. Chen Won Jung Choi Adolfo Correa Joanne E. Curran Mark J. Daly Susan K. Dutcher Patrick T. Ellinor Myriam Fornage Barry I. Freedman Stacey Gabriel Soren Germer Richard A. Gibbs Jiang He Kristian Hveem Gail P. Jarvik Robert C. Kaplan Sharon L. R. Kardia Eimear Kenny Ryan W. Kim Charles Kooperberg Cathy C. Laurie Seonwook Lee Don M. Lloyd-Jones Ruth J. F. Loos Steven A. Lubitz Rasika A. Mathias Karine A. Viaud Martinez Stephen T. McGarvey Braxton D. Mitchell Deborah A. Nickerson Kari E. North Aarno Palotie Cheol Joo Park Bruce M. Psaty D. C. Rao Susan Redline Alexander P. Reiner Daekwan Seo Jeong-Sun Seo Albert V. Smith Russell P. Tracy Ramachandran S. Vasan Sekar Kathiresan L. Adrienne Cupples Jerome I. Rotter Alanna C. Morrison Stephen S. Rich Samuli Ripatti Cristen Willer NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium FinnGen Gina M. Peloso |
| spellingShingle |
Pradeep Natarajan Akhil Pampana Sarah E. Graham Sanni E. Ruotsalainen James A. Perry Paul S. de Vries Jai G. Broome James P. Pirruccello Michael C. Honigberg Krishna Aragam Brooke Wolford Jennifer A. Brody Lucinda Antonacci-Fulton Moscati Arden Stella Aslibekyan Themistocles L. Assimes Christie M. Ballantyne Lawrence F. Bielak Joshua C. Bis Brian E. Cade Ron Do Harsha Doddapaneni Leslie S. Emery Yi-Jen Hung Marguerite R. Irvin Alyna T. Khan Leslie Lange Jiwon Lee Rozenn N. Lemaitre Lisa W. Martin Ginger Metcalf May E. Montasser Jee-Young Moon Donna Muzny Jeffrey R. O’Connell Nicholette D. Palmer Juan M. Peralta Patricia A. Peyser Adrienne M. Stilp Michael Tsai Fei Fei Wang Daniel E. Weeks Lisa R. Yanek James G. Wilson Goncalo Abecasis Donna K. Arnett Lewis C. Becker John Blangero Eric Boerwinkle Donald W. Bowden Yi-Cheng Chang Yii-Der I. Chen Won Jung Choi Adolfo Correa Joanne E. Curran Mark J. Daly Susan K. Dutcher Patrick T. Ellinor Myriam Fornage Barry I. Freedman Stacey Gabriel Soren Germer Richard A. Gibbs Jiang He Kristian Hveem Gail P. Jarvik Robert C. Kaplan Sharon L. R. Kardia Eimear Kenny Ryan W. Kim Charles Kooperberg Cathy C. Laurie Seonwook Lee Don M. Lloyd-Jones Ruth J. F. Loos Steven A. Lubitz Rasika A. Mathias Karine A. Viaud Martinez Stephen T. McGarvey Braxton D. Mitchell Deborah A. Nickerson Kari E. North Aarno Palotie Cheol Joo Park Bruce M. Psaty D. C. Rao Susan Redline Alexander P. Reiner Daekwan Seo Jeong-Sun Seo Albert V. Smith Russell P. Tracy Ramachandran S. Vasan Sekar Kathiresan L. Adrienne Cupples Jerome I. Rotter Alanna C. Morrison Stephen S. Rich Samuli Ripatti Cristen Willer NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium FinnGen Gina M. Peloso Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices Nature Communications |
| author_facet |
Pradeep Natarajan Akhil Pampana Sarah E. Graham Sanni E. Ruotsalainen James A. Perry Paul S. de Vries Jai G. Broome James P. Pirruccello Michael C. Honigberg Krishna Aragam Brooke Wolford Jennifer A. Brody Lucinda Antonacci-Fulton Moscati Arden Stella Aslibekyan Themistocles L. Assimes Christie M. Ballantyne Lawrence F. Bielak Joshua C. Bis Brian E. Cade Ron Do Harsha Doddapaneni Leslie S. Emery Yi-Jen Hung Marguerite R. Irvin Alyna T. Khan Leslie Lange Jiwon Lee Rozenn N. Lemaitre Lisa W. Martin Ginger Metcalf May E. Montasser Jee-Young Moon Donna Muzny Jeffrey R. O’Connell Nicholette D. Palmer Juan M. Peralta Patricia A. Peyser Adrienne M. Stilp Michael Tsai Fei Fei Wang Daniel E. Weeks Lisa R. Yanek James G. Wilson Goncalo Abecasis Donna K. Arnett Lewis C. Becker John Blangero Eric Boerwinkle Donald W. Bowden Yi-Cheng Chang Yii-Der I. Chen Won Jung Choi Adolfo Correa Joanne E. Curran Mark J. Daly Susan K. Dutcher Patrick T. Ellinor Myriam Fornage Barry I. Freedman Stacey Gabriel Soren Germer Richard A. Gibbs Jiang He Kristian Hveem Gail P. Jarvik Robert C. Kaplan Sharon L. R. Kardia Eimear Kenny Ryan W. Kim Charles Kooperberg Cathy C. Laurie Seonwook Lee Don M. Lloyd-Jones Ruth J. F. Loos Steven A. Lubitz Rasika A. Mathias Karine A. Viaud Martinez Stephen T. McGarvey Braxton D. Mitchell Deborah A. Nickerson Kari E. North Aarno Palotie Cheol Joo Park Bruce M. Psaty D. C. Rao Susan Redline Alexander P. Reiner Daekwan Seo Jeong-Sun Seo Albert V. Smith Russell P. Tracy Ramachandran S. Vasan Sekar Kathiresan L. Adrienne Cupples Jerome I. Rotter Alanna C. Morrison Stephen S. Rich Samuli Ripatti Cristen Willer NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium FinnGen Gina M. Peloso |
| author_sort |
Pradeep Natarajan |
| title |
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices |
| title_short |
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices |
| title_full |
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices |
| title_fullStr |
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices |
| title_full_unstemmed |
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices |
| title_sort |
chromosome xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-04-01 |
| description |
The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus. |
| url |
https://doi.org/10.1038/s41467-021-22339-1 |
| work_keys_str_mv |
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| _version_ |
1721522464264028160 |
| spelling |
doaj-09cb57a2d8544b5e803b374995f412e42021-04-18T11:13:48ZengNature Publishing GroupNature Communications2041-17232021-04-0112111410.1038/s41467-021-22339-1Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indicesPradeep Natarajan0Akhil Pampana1Sarah E. Graham2Sanni E. Ruotsalainen3James A. Perry4Paul S. de Vries5Jai G. Broome6James P. Pirruccello7Michael C. Honigberg8Krishna Aragam9Brooke Wolford10Jennifer A. Brody11Lucinda Antonacci-Fulton12Moscati Arden13Stella Aslibekyan14Themistocles L. Assimes15Christie M. Ballantyne16Lawrence F. Bielak17Joshua C. Bis18Brian E. Cade19Ron Do20Harsha Doddapaneni21Leslie S. Emery22Yi-Jen Hung23Marguerite R. Irvin24Alyna T. Khan25Leslie Lange26Jiwon Lee27Rozenn N. Lemaitre28Lisa W. Martin29Ginger Metcalf30May E. Montasser31Jee-Young Moon32Donna Muzny33Jeffrey R. O’Connell34Nicholette D. Palmer35Juan M. Peralta36Patricia A. Peyser37Adrienne M. Stilp38Michael Tsai39Fei Fei Wang40Daniel E. Weeks41Lisa R. Yanek42James G. Wilson43Goncalo Abecasis44Donna K. Arnett45Lewis C. Becker46John Blangero47Eric Boerwinkle48Donald W. Bowden49Yi-Cheng Chang50Yii-Der I. Chen51Won Jung Choi52Adolfo Correa53Joanne E. Curran54Mark J. Daly55Susan K. Dutcher56Patrick T. Ellinor57Myriam Fornage58Barry I. Freedman59Stacey Gabriel60Soren Germer61Richard A. Gibbs62Jiang He63Kristian Hveem64Gail P. Jarvik65Robert C. Kaplan66Sharon L. R. Kardia67Eimear Kenny68Ryan W. Kim69Charles Kooperberg70Cathy C. Laurie71Seonwook Lee72Don M. Lloyd-Jones73Ruth J. F. Loos74Steven A. Lubitz75Rasika A. Mathias76Karine A. Viaud Martinez77Stephen T. McGarvey78Braxton D. Mitchell79Deborah A. Nickerson80Kari E. North81Aarno Palotie82Cheol Joo Park83Bruce M. Psaty84D. C. Rao85Susan Redline86Alexander P. Reiner87Daekwan Seo88Jeong-Sun Seo89Albert V. Smith90Russell P. Tracy91Ramachandran S. Vasan92Sekar Kathiresan93L. Adrienne Cupples94Jerome I. Rotter95Alanna C. Morrison96Stephen S. Rich97Samuli Ripatti98Cristen Willer99NHLBI Trans-Omics for Precision Medicine (TOPMed) ConsortiumFinnGenGina M. Peloso100Cardiovascular Research Center, Massachusetts General HospitalCardiovascular Research Center, Massachusetts General HospitalDepartment of Internal Medicine: Cardiology, University of MichiganInstitute for Molecular Medicine Finland, University of HelsinkiUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic MedicineHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at HoustonDepartment of Biostatistics, University of WashingtonCardiovascular Research Center, Massachusetts General HospitalCardiovascular Research Center, Massachusetts General HospitalCardiovascular Research Center, Massachusetts General HospitalDepartment of Computational Medicine and Bioinformatics, University of MichiganCardiovascular Health Research Unit, Department of Medicine, University of WashingtonThe McDonnell Genome Institute, Washington University School of MedicineThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount SinaiDepartment of Epidemiology, School of Public Health, University of Alabama at BirminghamDepartment of Medicine, Stanford University School of MedicineSection of Cardiovascular Research, Baylor College of MedicineDepartment of Epidemiology, School of Public Health, University of MichiganCardiovascular Health Research Unit, Department of Medicine, University of WashingtonDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount SinaiHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Biostatistics, University of WashingtonDivision of Endocrine and Metabolism, Tri-Service General Hospital Songshan branchDepartment of Epidemiology, School of Public Health, University of Alabama at BirminghamDepartment of Biostatistics, University of WashingtonDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical CampusDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolCardiovascular Health Research Unit, Department of Medicine, University of WashingtonDivision of Cardiology, George Washington University School of Medicine and Healthcare SciencesHuman Genome Sequencing Center, Baylor College of MedicineUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic MedicineDepartment of Epidemiology and Population Health, Albert Einstein College of MedicineHuman Genome Sequencing Center, Baylor College of MedicineUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic MedicineDepartment of Biochemistry, Wake Forest School of MedicineDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of MedicineDepartment of Epidemiology, School of Public Health, University of MichiganDepartment of Biostatistics, University of WashingtonDepartment of Laboratory Medicine and Pathology, University of MinnesotaDepartment of Biostatistics, University of WashingtonDepartments of Human Genetics and Biostatistics, University of Pittsburgh, PittsburghDepartment of Medicine, Johns Hopkins University School of MedicineDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical CenterDepartment of Biostatistics, University of MichiganDeans office, School of Public Health, University of KentuckyDepartment of Medicine, Johns Hopkins University School of MedicineDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of MedicineHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at HoustonDepartment of Biochemistry, Wake Forest School of MedicineDepartment of Internal Medicine, National Taiwan University HospitalThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterPsomagen. Inc. (formerly Macrogen USA)Department of Medicine, University of Mississippi Medical CenterDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of MedicineProgram in Medical and Population Genetics, Broad InstituteThe McDonnell Genome Institute, Washington University School of MedicineProgram in Medical and Population Genetics, Broad InstituteInstitute of Molecular Medicine, the University of Texas Health Science Center at HoustonDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Genomics Platform, Broad Institute of Harvard and MITNew York Genome CenterHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, and Tulane University Translational Science Institute, Tulane UniversityDepartment of Public Health and General Practice, HUNT Research Centre, Norwegian University of Science and TechnologyDepartments of Medicine (Medical Genetics) and Genome Sciences, University of WashingtonDepartment of Epidemiology and Population Health, Albert Einstein College of MedicineDepartment of Epidemiology, School of Public Health, University of MichiganThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount SinaiPsomagen. Inc. (formerly Macrogen USA)Division of Public Health Sciences, Fred Hutchinson Cancer Research CenterDepartment of Biostatistics, University of WashingtonPsomagen. Inc. (formerly Macrogen USA)Preventive Medicine, Feinberg School of Medicine, Northwestern UniversityThe Charles Bronfman Institute for Personalized Medicine, Ichan School of Medicine at Mount SinaiCardiac Arrhythmia Service and Cardiovascular Research Center Massachusetts General HospitalDepartment of Medicine, Johns Hopkins University School of MedicineIllumina Laboratory Services, Illumina inc.Department of Epidemiology and International Health Institute, Brown UniversityUniversity of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition and Program for Personalized and Genomic MedicineDepartment of Genome Sciences, University of WashingtonDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel HillProgram in Medical and Population Genetics, Broad InstitutePsomagen. Inc. (formerly Macrogen USA)Cardiovascular Health Research Unit, Department of Medicine, University of WashingtonDivision of Biostatistics, Washington University School of MedicineDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterPsomagen. Inc. (formerly Macrogen USA)Psomagen. Inc. (formerly Macrogen USA)Department of Biostatistics, University of MichiganDepartments of Pathology & Laboratory Medicine and Biochemistry, Larrner College of Medicine, University of VermontSections of Preventive Medicine and Epidemiology and Cardiology, Department of Medicine, Boston University School of MedicineProgram in Medical and Population Genetics, Broad InstituteNHLBI Framingham Heart StudyThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at HoustonCenter for Public Health Genomics, University of VirginiaProgram in Medical and Population Genetics, Broad InstituteDepartment of Internal Medicine: Cardiology, University of MichiganDepartment of Biostatistics, Boston University School of Public HealthThe influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.https://doi.org/10.1038/s41467-021-22339-1 |