Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines

Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines

Abstract Background Phospholipases A 2 (PLA 2 s) are abundant components of snake venoms that have been extensively studied due to their pharmacological and pathophysiological effects on living organisms. This study aimed to assess the antitumor potential of BthTX-I, a basic myotoxic PLA 2isolated...

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Bibliographic Details
Main Authors: Cássio Prinholato da Silva, Tássia R. Costa, Raquel M. Alves Paiva, Adélia C. O. Cintra, Danilo L. Menaldo, Lusânia M. Greggi Antunes, Suely V. Sampaio
Format: Article
Language:English
Published: SciELO 2015-12-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Bothrops jararacussu
BthTX-I
Antitumor potential
Apoptosis
Cell cycle alterations
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100348&lng=en&tlng=en

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