Possible Role of Interleukin-6 in Rheumatoid Arthritis
Background: Rheumatoid Arthritis (RA) is an autoimmune disease. Many etiological agents are proposed to play a role in its pathogenecity. One of these factors is cytokines such as Interleukin6. Material & Methods: ELISA method has been used for IL-6 estimation in 75 RA patients in comparison wi...
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Faculty of Medicine University of Baghdad
2007-07-01
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doaj-09e408f438b14e0f8daceac17d3b1c3b2020-11-25T02:22:11ZengFaculty of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572007-07-01492Possible Role of Interleukin-6 in Rheumatoid ArthritisBatool A. Al-Haidary0Clinical Immunology/ Ass. Prof./ College of Medical & Health Technology. Background: Rheumatoid Arthritis (RA) is an autoimmune disease. Many etiological agents are proposed to play a role in its pathogenecity. One of these factors is cytokines such as Interleukin6. Material & Methods: ELISA method has been used for IL-6 estimation in 75 RA patients in comparison with 61 SLE as patient controls and 39 apparently healthy controls. Results: This study showed that there was an elevation of IL-6 in the sera of RA patients with high significant differences between RA patients and controls (P< 0.001). Moreover a good correlation between IL-6 level & RF titer were observed. However, for most patients with high IL-6 were shown to be HLA-DR4. Conclusions: Interleukin-6 play a crucial role in the disease which may be participate in the severity of RA & subsequently its treatment. http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1389RA, IL-6, RF, HLA-DR4, ELISA, Microlymphocytotoxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Batool A. Al-Haidary |
spellingShingle |
Batool A. Al-Haidary Possible Role of Interleukin-6 in Rheumatoid Arthritis مجلة كلية الطب RA, IL-6, RF, HLA-DR4, ELISA, Microlymphocytotoxicity |
author_facet |
Batool A. Al-Haidary |
author_sort |
Batool A. Al-Haidary |
title |
Possible Role of Interleukin-6 in Rheumatoid Arthritis |
title_short |
Possible Role of Interleukin-6 in Rheumatoid Arthritis |
title_full |
Possible Role of Interleukin-6 in Rheumatoid Arthritis |
title_fullStr |
Possible Role of Interleukin-6 in Rheumatoid Arthritis |
title_full_unstemmed |
Possible Role of Interleukin-6 in Rheumatoid Arthritis |
title_sort |
possible role of interleukin-6 in rheumatoid arthritis |
publisher |
Faculty of Medicine University of Baghdad |
series |
مجلة كلية الطب |
issn |
0041-9419 2410-8057 |
publishDate |
2007-07-01 |
description |
Background: Rheumatoid Arthritis (RA) is an autoimmune disease. Many etiological agents are proposed to play a role in its pathogenecity. One of these factors is cytokines such as Interleukin6.
Material & Methods: ELISA method has been used for IL-6 estimation in 75 RA patients in comparison with 61 SLE as patient controls and 39 apparently healthy controls.
Results: This study showed that there was an elevation of IL-6 in the sera of RA patients with high significant differences between RA patients and controls (P< 0.001). Moreover a good correlation between IL-6 level & RF titer were observed. However, for most patients with high IL-6 were shown to be HLA-DR4.
Conclusions: Interleukin-6 play a crucial role in the disease which may be participate in the severity of RA & subsequently its treatment.
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topic |
RA, IL-6, RF, HLA-DR4, ELISA, Microlymphocytotoxicity |
url |
http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1389 |
work_keys_str_mv |
AT batoolaalhaidary possibleroleofinterleukin6inrheumatoidarthritis |
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