Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus
Cinnamaldehyde (CA) is marginally soluble in water, making it challenging to evenly disperse it in foods, and resulting in lowered anti-A. flavus efficacy. In the present study, nano-dispersed CA (nano-CA) was prepared to increase its aqueous solubility. Free and nano-dispersed CA were compared in t...
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doaj-09ecc0e5636a486aa55aced18da2698b2020-11-25T01:22:20ZengMDPI AGMolecules1420-30492015-04-012046022603210.3390/molecules20046022molecules20046022Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavusHongbo Li0Qingshan Shen1Wei Zhou2Haizhen Mo3Daodong Pan4Liangbin Hu5School of Marine Science, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, ChinaDepartment of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, ChinaDepartment of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, ChinaSchool of Marine Science, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, ChinaCinnamaldehyde (CA) is marginally soluble in water, making it challenging to evenly disperse it in foods, and resulting in lowered anti-A. flavus efficacy. In the present study, nano-dispersed CA (nano-CA) was prepared to increase its aqueous solubility. Free and nano-dispersed CA were compared in terms of their inhibitory activity against fungal growth and aflatoxin production of A. flavus both in Sabouraud Dextrose (SD) culture and in peanut butter. Our results indicated that free CA inhibited the mycelia growth and aflatoxin production of A. flavus with a minimal inhibitory concentration (MIC) value of 1.0 mM, but promoted the aflatoxin production at some concentrations lower than the MIC. Nano-CA had a lower MIC value of 0.8 mM against A. flavus, and also showed improved activity against aflatoxin production without the promotion at lower dose. The solidity of peanut butter had an adverse impact on the antifungal activity of free CA, whereas nano-dispersed CA showed more than 2-fold improved activity against the growth of A. flavus. Free CA still promoted AFB1 production at the concentration of 0.25 mM, whereas nano-CA showed more efficient inhibition of AFB1 production in the butter.http://www.mdpi.com/1420-3049/20/4/6022cinnamaldehydenano-dispersionaflatoxininhibitionpeanut butter |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hongbo Li Qingshan Shen Wei Zhou Haizhen Mo Daodong Pan Liangbin Hu |
spellingShingle |
Hongbo Li Qingshan Shen Wei Zhou Haizhen Mo Daodong Pan Liangbin Hu Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus Molecules cinnamaldehyde nano-dispersion aflatoxin inhibition peanut butter |
author_facet |
Hongbo Li Qingshan Shen Wei Zhou Haizhen Mo Daodong Pan Liangbin Hu |
author_sort |
Hongbo Li |
title |
Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus |
title_short |
Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus |
title_full |
Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus |
title_fullStr |
Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus |
title_full_unstemmed |
Nanocapsular Dispersion of Cinnamaldehyde for Enhanced Inhibitory Activity against Aflatoxin Production by Aspergillus flavus |
title_sort |
nanocapsular dispersion of cinnamaldehyde for enhanced inhibitory activity against aflatoxin production by aspergillus flavus |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2015-04-01 |
description |
Cinnamaldehyde (CA) is marginally soluble in water, making it challenging to evenly disperse it in foods, and resulting in lowered anti-A. flavus efficacy. In the present study, nano-dispersed CA (nano-CA) was prepared to increase its aqueous solubility. Free and nano-dispersed CA were compared in terms of their inhibitory activity against fungal growth and aflatoxin production of A. flavus both in Sabouraud Dextrose (SD) culture and in peanut butter. Our results indicated that free CA inhibited the mycelia growth and aflatoxin production of A. flavus with a minimal inhibitory concentration (MIC) value of 1.0 mM, but promoted the aflatoxin production at some concentrations lower than the MIC. Nano-CA had a lower MIC value of 0.8 mM against A. flavus, and also showed improved activity against aflatoxin production without the promotion at lower dose. The solidity of peanut butter had an adverse impact on the antifungal activity of free CA, whereas nano-dispersed CA showed more than 2-fold improved activity against the growth of A. flavus. Free CA still promoted AFB1 production at the concentration of 0.25 mM, whereas nano-CA showed more efficient inhibition of AFB1 production in the butter. |
topic |
cinnamaldehyde nano-dispersion aflatoxin inhibition peanut butter |
url |
http://www.mdpi.com/1420-3049/20/4/6022 |
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