Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi.

Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi.

The oxidative lesion 8-oxoguanine (8-oxoG) is removed during base excision repair by the 8-oxoguanine DNA glycosylase 1 (Ogg1). This lesion can erroneously pair with adenine, and the excision of this damaged base by Ogg1 enables the insertion of a guanine and prevents DNA mutation. In this report, w...

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Main Authors: Carolina Furtado, Marianna Kunrath-Lima, Matheus Andrade Rajão, Isabela Cecília Mendes, Michelle Barbi de Moura, Priscila Carneiro Campos, Andrea Mara Macedo, Glória Regina Franco, Sérgio Danilo Junho Pena, Santuza Maria Ribeiro Teixeira, Bennett Van Houten, Carlos Renato Machado
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3411635?pdf=render

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